MR-guided laser interstitial thermal therapy in the treatment of brain tumors and epilepsy.

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2024-08-21 DOI:10.1007/s00701-024-06238-0

Silas Haahr Nielsen, Rune Rasmussen

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Abstract

MR-guided Laser Interstitial Thermal Therapy (MRgLITT) is a minimally invasive neurosurgical technique increasingly used for the treatment of drug-resistant epilepsy and brain tumors. Utilizing near-infrared light energy delivery guided by real-time MRI thermometry, MRgLITT enables precise ablation of targeted brain tissues, resulting in limited corridor-related morbidity and expedited postoperative recovery. Since receiving CE marking in 2018, the adoption of MRgLITT has expanded to more than 40 neurosurgical centers across Europe. In epilepsy treatment, MRgLITT can be applied to various types of focal lesional epilepsy, including mesial temporal lobe epilepsy, hypothalamic hamartoma, focal cortical dysplasias, periventricular heterotopias, cavernous malformations, dysembryoplastic neuroepithelial tumors (DNET), low-grade gliomas, tuberous sclerosis, and in disconnective surgeries. In neuro-oncology, MRgLITT is used for treating newly diagnosed and recurrent primary brain tumors, brain metastases, and radiation necrosis. This comprehensive review presents an overview of the current evidence and technical considerations for the use of MRgLITT in treating various pathologies associated with drug-resistant epilepsy and brain tumors.

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磁共振引导下的激光间质热疗法在脑肿瘤和癫痫治疗中的应用。

磁共振引导下的激光间质热疗（MRgLITT）是一种微创神经外科技术，越来越多地用于治疗耐药性癫痫和脑肿瘤。MRgLITT 利用实时核磁共振测温引导的近红外光能量传递，实现了对目标脑组织的精确消融，从而限制了走廊相关的发病率，加快了术后恢复。自2018年获得CE认证以来，MRgLITT的应用已扩展到欧洲40多个神经外科中心。在癫痫治疗方面，MRgLITT可应用于各种类型的局灶性病变癫痫，包括颞叶中叶癫痫、下丘脑火腿肠瘤、局灶性皮质发育不良、脑室周围异位症、海绵状畸形、胚胎发育不良性神经上皮肿瘤（DNET）、低级别胶质瘤、结节性硬化症以及断裂手术。在神经肿瘤学中，MRgLITT 用于治疗新诊断和复发的原发性脑肿瘤、脑转移瘤和放射性坏死。本综合综述概述了使用 MRgLITT 治疗与耐药性癫痫和脑肿瘤相关的各种病症的现有证据和技术注意事项。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.