Biomedical application of microalgal-biomaterials hybrid system

IF 3.2 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

Biotechnology Journal Pub Date : 2024-08-21 DOI:10.1002/biot.202400325

Yize Li, Yali Fan, Shuo Ye, Lingyun Xu, Gezhen Wang, Yuli Lu, Suxiang Huang, Yingying Zhang

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引用次数: 0

Abstract

Microalgae are a group of microorganisms containing chlorophyll A, which are highly photosynthetic and rich in nutrients. And they can produce multiple bioactive substances (peptides, proteins, polysaccharides, and fatty acids) for biomedical applications. Despite the unique advantages of microalgae-based biotherapy, the insufficient treatment efficiency limits its further application. With the development of nanotechnology, the combination of microalgae and biomaterials can improve therapeutic efficacies, which has attracted increasing attention. In this microalgal-biomaterials hybrid system, biomaterials with excellent optical and magnetic properties play an important role in biological therapy. Microalgae, as a natural vehicle, can increase oxygen content and alleviate hypoxia in diseased areas, further enhancing therapeutic effects. In this review, the synergistic therapeutic effects of microalgal-biomaterials hybrid system in different diseases (cancer, myocardial infarction, ischemia stroke, chronic infection, and intestinal diseases) are comprehensively summarized.

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微藻-生物材料混合系统的生物医学应用。

微藻是一类含有叶绿素 A 的微生物，具有高度光合作用和丰富的营养物质。它们能产生多种生物活性物质（肽、蛋白质、多糖和脂肪酸），可用于生物医学领域。尽管微藻生物疗法具有独特的优势，但由于治疗效率不高，限制了其进一步应用。随着纳米技术的发展，微藻与生物材料的结合可以提高治疗效果，这已引起越来越多的关注。在微藻-生物材料混合系统中，具有优异光学和磁学特性的生物材料在生物治疗中发挥着重要作用。微藻作为一种天然载体，可以增加氧含量，缓解患病区域的缺氧状况，进一步提高治疗效果。本综述全面总结了微藻-生物材料混合系统在不同疾病（癌症、心肌梗塞、缺血性中风、慢性感染和肠道疾病）中的协同治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology Journal Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

8.90

自引率

2.10%

发文量

123

审稿时长

1.5 months

期刊介绍： Biotechnology Journal (2019 Journal Citation Reports: 3.543) is fully comprehensive in its scope and publishes strictly peer-reviewed papers covering novel aspects and methods in all areas of biotechnology. Some issues are devoted to a special topic, providing the latest information on the most crucial areas of research and technological advances. In addition to these special issues, the journal welcomes unsolicited submissions for primary research articles, such as Research Articles, Rapid Communications and Biotech Methods. BTJ also welcomes proposals of Review Articles - please send in a brief outline of the article and the senior author''s CV to the editorial office. BTJ promotes a special emphasis on: Systems Biotechnology Synthetic Biology and Metabolic Engineering Nanobiotechnology and Biomaterials Tissue engineering, Regenerative Medicine and Stem cells Gene Editing, Gene therapy and Immunotherapy Omics technologies Industrial Biotechnology, Biopharmaceuticals and Biocatalysis Bioprocess engineering and Downstream processing Plant Biotechnology Biosafety, Biotech Ethics, Science Communication Methods and Advances.