Framework for predicting alloreactivity in hematopoietic cell transplants

IF 33.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nature biotechnology Pub Date : 2024-08-21 DOI:10.1038/s41587-024-02354-5

引用次数: 0

Abstract

The therapeutic principle of allogeneic hematopoietic cell transplantation, one the most common forms of cancer immunotherapy, is alloreactivity, yet its molecular determinants remain largely unknown. An analytical framework now enables personalized assessment of alloreactivity from whole-exome sequencing of donor–recipient pairs, to help with prognostication of disease relapse and immune-mediated complications.

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预测造血细胞移植异体反应的框架

异体造血细胞移植是癌症免疫疗法中最常见的一种，其治疗原理是异体反应，但其分子决定因素在很大程度上仍不为人所知。现在有了一个分析框架，可以通过对供体和受体配对进行全外显子组测序，对异体反应进行个性化评估，从而帮助预测疾病复发和免疫介导的并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature biotechnology 工程技术-生物工程与应用微生物

CiteScore

63.00

自引率

1.70%

发文量

382

审稿时长

3 months

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