Renewed insights into Ackermannviridae phage biology and applications

npj Viruses Pub Date : 2024-08-21 DOI:10.1038/s44298-024-00046-0

Anders Nørgaard Sørensen, Lone Brøndsted

{"title":"Renewed insights into Ackermannviridae phage biology and applications","authors":"Anders Nørgaard Sørensen, Lone Brøndsted","doi":"10.1038/s44298-024-00046-0","DOIUrl":null,"url":null,"abstract":"The Ackermannviridae family was established in 2017, containing phages previously classified within the Myoviridae family under the Viunalikevirus genus. Ackermannviridae phages have been increasingly studied due to their broad range of hosts among Enterobacteriaceae, and currently, 174 complete genomes are available on NCBI. Instrumental for their wide host infectivity, Ackermannviridae phages display a branched complex of multiple Tail Spike Proteins (TSPs). These TSPs recognize diverse surface polysaccharide receptors, allowing the phages to target strains with distinct lipopolysaccharides or capsular polysaccharides. This review gives an updated overview of the taxonomy and hosts of the expanding Ackermannviridae family with significant emphasis on recent advances in structural and computational biology for elucidating TSP diversity, structural domains, and assembly of the branched TSP complex. Furthermore, we explore the potential of engineering Ackermannviridae phages and discuss the challenges of using transducing wildtype phages for biocontrol. Finally, this review identifies bottlenecks hindering further advances in understanding Ackermannviridae phage biology and applications.","PeriodicalId":494217,"journal":{"name":"npj Viruses","volume":" ","pages":"1-11"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44298-024-00046-0.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Viruses","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44298-024-00046-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

The Ackermannviridae family was established in 2017, containing phages previously classified within the Myoviridae family under the Viunalikevirus genus. Ackermannviridae phages have been increasingly studied due to their broad range of hosts among Enterobacteriaceae, and currently, 174 complete genomes are available on NCBI. Instrumental for their wide host infectivity, Ackermannviridae phages display a branched complex of multiple Tail Spike Proteins (TSPs). These TSPs recognize diverse surface polysaccharide receptors, allowing the phages to target strains with distinct lipopolysaccharides or capsular polysaccharides. This review gives an updated overview of the taxonomy and hosts of the expanding Ackermannviridae family with significant emphasis on recent advances in structural and computational biology for elucidating TSP diversity, structural domains, and assembly of the branched TSP complex. Furthermore, we explore the potential of engineering Ackermannviridae phages and discuss the challenges of using transducing wildtype phages for biocontrol. Finally, this review identifies bottlenecks hindering further advances in understanding Ackermannviridae phage biology and applications.

Abstract Image

查看原文本刊更多论文

对阿克曼病毒科噬菌体生物学和应用的新认识

阿克曼病毒科（Ackermannviridae）成立于 2017 年，包含以前归入 Myoviridae 科 Viunalikevirus 属下的噬菌体。由于阿克曼病毒科噬菌体在肠杆菌科中的宿主范围很广，对它们的研究也越来越多，目前，NCBI 上已经提供了 174 个完整的基因组。阿克曼病毒科噬菌体具有广泛的宿主感染性，它显示了由多个尾刺蛋白（TSP）组成的分支复合物。这些尾刺蛋白能识别不同的表面多糖受体，使噬菌体能以具有不同脂多糖或囊多糖的菌株为目标。本综述概述了不断扩大的阿克曼病毒科的分类和宿主，重点介绍了结构生物学和计算生物学在阐明 TSP 多样性、结构域和支链 TSP 复合物组装方面的最新进展。此外，我们还探讨了阿克曼病毒科噬菌体工程学的潜力，并讨论了使用转导野生型噬菌体进行生物控制所面临的挑战。最后，本综述指出了阻碍进一步了解阿克曼病毒科噬菌体生物学和应用的瓶颈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

npj Viruses

自引率

0.00%

发文量