A Model for Estimating the Burden of Disease of Transfusion-Transmitted Infection.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI:10.3389/ijph.2024.1607165
William Riley, Kailey Love, Mary Saxon, Aaron Tobian, Evan M Bloch, Ronnie Kasirye, Irene Lubega, Ezra Musisi, Aggrey Dhabangi, Dorothy Kyeyune, Jeffrey McCullough
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引用次数: 0

Abstract

Objectives: Blood transfusion is an important mode of infectious disease transmission in low- and middle-income countries (LMICs). This study describes a model to determine the prevalence of transfusion-transmitted infections (TTIs) and the associated burden of disease.

Methods: A five-step model was developed to determine the TTI-related burden of disease measured by disability-adjusted life years (DALYs). Uganda was selected as the study country.

Results: Approximately 298,266 units of blood were transfused in Uganda in 2019, yielding an estimated TTI incidence of 6,858 new TTIs (2.3% of transfused units) and prevalence of 19,141 TTIs (6.4% of transfused units). The total burden of disease is 2,903 DALYs, consisting of approximately 2,590 years of life lost (YLLs), and 313 years lived with disability (YLDs).

Conclusion: The incidence and prevalence of TTIs and the associated burden of disease can be calculated on a local and national level. The model can be applied by health ministries to estimate the impact of TTIs in order to develop blood safety strategies to reduce the burden of disease.

输血传播感染疾病负担估算模型。
目的:输血是中低收入国家(LMICs)传染病传播的重要方式。本研究介绍了一种确定输血传播感染流行率和相关疾病负担的模型:方法:研究人员开发了一个五步模型,用于确定与输血传播感染相关的疾病负担(以残疾调整生命年衡量)。乌干达被选为研究国家:2019 年,乌干达输血约 298,266 单位,估计新发 TTI 为 6,858 例(占输血单位的 2.3%),患病率为 19,141 例(占输血单位的 6.4%)。疾病总负担为 2,903 DALYs,包括约 2,590 年的寿命损失(YLLs)和 313 年的残疾寿命(YLDs):结论:创伤性脑损伤的发病率和流行率以及相关的疾病负担可以在地方和国家层面进行计算。卫生部门可利用该模型估算创伤性肠梗阻的影响,从而制定血液安全策略,减轻疾病负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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