Comparison of the effectiveness of diclofenac sodium and tenoxicam in the prevention of epidural fibrosis by topical application with an absorbable gelatin sponge on the dura in an experimental laminectomy model.

IF 1.5 4区 医学 Q4 NEUROSCIENCES
Sule Gokturk, Yasin Gokturk, Suat Erol Celik
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引用次数: 0

Abstract

Introduction: There has been an increasing trend in spinal surgery interventions in recent years. Low back pain is a disorder that is seen at least once in the lifetime of approximately 80% of the general population. Today, neurosurgeons perform operations including laminectomy for various reasons. Epidural fibrosis is a scar tissue that develops after posterior spinal surgery. Various synthetic and organic materials have been used in experimental studies to prevent epidural fibrosis in laminectomy defects. In this study we aimed to investigate and observe histopathologically the effectiveness of cyclooxygenase inhibitor drugs; tenoxicam and diclofenac sodium in the experimental rat laminectomy model in preventing the postoperative spinal epidural fibrosis.

Material and methods: In this study, 32 Wistar-Albino female rats were used. 8 mg/kg tenoxicam and 1.5 mg/kg diclofenac sodium were applied on the dura with an absorbable gelatin sponge. After decapitation, L1-L4 laminectomy area was totally removed and histopathological examination was performed.

Results and conclusions: It has been shown that the topical application of diclofenac sodium and tenoxicam, which are selective Cox inhibitor drugs, prevents fibroblast migration by forming a local barrier and Cox inhibitors are caused by the inhibition of prostanoids, which are inflammatory mediators.

比较双氯芬酸钠和替诺昔康在实验性椎板切除术模型中使用可吸收明胶海绵局部涂抹硬脑膜以预防硬脑膜外纤维化的效果。
导言:近年来,脊柱外科手术干预呈上升趋势。大约 80% 的普通人一生中至少会出现一次腰背痛。如今,神经外科医生出于各种原因实施包括椎板切除术在内的手术。硬膜外纤维化是脊柱后路手术后形成的疤痕组织。实验研究中使用了各种合成材料和有机材料来防止椎板切除术缺损的硬膜外纤维化。本研究旨在从组织病理学角度研究和观察环氧化酶抑制剂药物替诺昔康和双氯芬酸钠在实验性大鼠椎板切除模型中预防术后脊髓硬膜外纤维化的效果:本研究使用了32只Wistar-Albino雌性大鼠。用可吸收明胶海绵将 8 mg/kg 替诺昔康和 1.5 mg/kg 双氯芬酸钠涂抹在硬膜上。斩首后,完全切除 L1-L4 椎板切除区,并进行组织病理学检查:结果表明,局部应用双氯芬酸钠和替诺昔康这两种选择性 Cox 抑制剂药物可通过形成局部屏障阻止成纤维细胞迁移,而 Cox 抑制剂是通过抑制炎症介质前列腺素引起的。
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来源期刊
Folia neuropathologica
Folia neuropathologica 医学-病理学
CiteScore
2.50
自引率
5.00%
发文量
38
审稿时长
>12 weeks
期刊介绍: Folia Neuropathologica is an official journal of the Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. The journal publishes original articles and reviews that deal with all aspects of clinical and experimental neuropathology and related fields of neuroscience research. The scope of journal includes surgical and experimental pathomorphology, ultrastructure, immunohistochemistry, biochemistry and molecular biology of the nervous tissue. Papers on surgical neuropathology and neuroimaging are also welcome. The reports in other fields relevant to the understanding of human neuropathology might be considered.
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