Therapeutic effect of computed tomography-guided dorsal root ganglion pulsed radiofrequency regulation combined with platelet-rich plasma injection on postherpetic neuralgia: A retrospective study.

IF 1.5 4区医学 Q4 NEUROSCIENCES

Folia neuropathologica Pub Date : 2024-08-21 DOI:10.5114/fn.2024.136436

Zhongwei Wang, Jing Chen, Xiaona Guo, Yan Lin, Weipeng Ge, Yunchao Chu

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引用次数: 0

Abstract

Introduction: Postherpetic neuralgia (PHN) is one of the common refractory neuropathic pains. Oral drug treatment has great side effects and poor efficacy. To study the efficacy of computed tomography (CT)-guided pulsed radiofrequency (PRF) targeting dorsal root ganglion (DRG) and platelet-rich plasma (PRP), this retrospective observation was performed.

Material and methods: All patients with PHN were divided into the control group, PRF group, and PRF + PRP group based on their different treatment methods. The control group (45 cases) received drug treatment, the PRF group (45 cases) received CT-guided PRF treatment targeted to DRG, and the PRF + PRP group received PRF and PRP treatment. The changes of the numeric rating scale (NRS), Pittsburgh sleep quality index (PSQI) levels, and short form 36 health survey questionnaire (SF-36) before treatment and 7 days, 14 days, 30 days, and 90 days after treatment were compared among three groups.

Results: NRS and PSQI scores in the PRF + PRP group were lower than those in the PRF group and control group at 90 days after treatment ( p < 0.001). At 90 days after the operation, the scores of SF-36 in the PRF + PRP group were obviously elevated compared with the data of the control group and PRF group ( p < 0.001).

Conclusions: The pain degree, quality of sleep of patients, and quality of life with PHN were significantly improved after PRF combined with PRP treatments.

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计算机断层扫描引导下背根神经节脉冲射频调节联合富血小板血浆注射对带状疱疹后遗神经痛的治疗效果：回顾性研究。

简介带状疱疹后遗神经痛（PHN）是常见的难治性神经痛之一。口服药物治疗副作用大、疗效差。为了研究计算机断层扫描（CT）引导下针对背根神经节（DRG）的脉冲射频（PRF）和富血小板血浆（PRP）的疗效，本研究进行了回顾性观察：根据不同的治疗方法，将所有 PHN 患者分为对照组、PRF 组和 PRF + PRP 组。对照组（45 例）接受药物治疗，PRF 组（45 例）接受 CT 引导下针对 DRG 的 PRF 治疗，PRF + PRP 组接受 PRF 和 PRP 治疗。比较三组患者治疗前、治疗后 7 天、14 天、30 天和 90 天的数字评分量表（NRS）、匹兹堡睡眠质量指数（PSQI）水平和 36 项健康调查问卷（SF-36）的变化：结果：治疗后 90 天，PRF + PRP 组的 NRS 和 PSQI 评分低于 PRF 组和对照组（P < 0.001）。术后 90 天，PRF + PRP 组 SF-36 评分明显高于对照组和 PRF 组（P < 0.001）：结论：PRF 联合 PRP 治疗后，PHN 患者的疼痛程度、睡眠质量和生活质量均有明显改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Folia neuropathologica 医学-病理学

CiteScore

2.50

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Folia Neuropathologica is an official journal of the Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. The journal publishes original articles and reviews that deal with all aspects of clinical and experimental neuropathology and related fields of neuroscience research. The scope of journal includes surgical and experimental pathomorphology, ultrastructure, immunohistochemistry, biochemistry and molecular biology of the nervous tissue. Papers on surgical neuropathology and neuroimaging are also welcome. The reports in other fields relevant to the understanding of human neuropathology might be considered.

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