Microbial conversion of ethanol to high-value products: progress and challenges

IF 6.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology for Biofuels Pub Date : 2024-08-19 DOI:10.1186/s13068-024-02546-w

Manman Sun, Alex Xiong Gao, Xiuxia Liu, Zhonghu Bai, Peng Wang, Rodrigo Ledesma-Amaro

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引用次数: 0

Abstract

Industrial biotechnology heavily relies on the microbial conversion of carbohydrate substrates derived from sugar- or starch-rich crops. This dependency poses significant challenges in the face of a rising population and food scarcity. Consequently, exploring renewable, non-competing carbon sources for sustainable bioprocessing becomes increasingly important. Ethanol, a key C2 feedstock, presents a promising alternative, especially for producing acetyl-CoA derivatives. In this review, we offer an in-depth analysis of ethanol's potential as an alternative carbon source, summarizing its distinctive characteristics when utilized by microbes, microbial ethanol metabolism pathway, and microbial responses and tolerance mechanisms to ethanol stress. We provide an update on recent progress in ethanol-based biomanufacturing and ethanol biosynthesis, discuss current challenges, and outline potential research directions to guide future advancements in this field. The insights presented here could serve as valuable theoretical support for researchers and industry professionals seeking to harness ethanol's potential for the production of high-value products.

Graphic Abstract

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微生物将乙醇转化为高价值产品：进展与挑战。

工业生物技术在很大程度上依赖于从含糖或淀粉丰富的作物中提取的碳水化合物底物的微生物转化。面对人口增长和粮食短缺，这种依赖性带来了巨大挑战。因此，为可持续生物加工探索可再生、非竞争性碳源变得越来越重要。乙醇作为一种关键的 C2 原料，是一种前景广阔的替代品，尤其是在生产乙酰-CoA 衍生物方面。在这篇综述中，我们深入分析了乙醇作为替代碳源的潜力，总结了乙醇被微生物利用时的显著特点、微生物乙醇代谢途径以及微生物对乙醇压力的反应和耐受机制。我们介绍了乙醇生物制造和乙醇生物合成的最新进展，讨论了当前面临的挑战，并概述了潜在的研究方向，以指导该领域未来的发展。本文提出的见解可为寻求利用乙醇潜力生产高价值产品的研究人员和行业专业人士提供宝贵的理论支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology for Biofuels 工程技术-生物工程与应用微生物

自引率

0.00%

发文量

审稿时长

2.7 months

期刊介绍： Biotechnology for Biofuels is an open access peer-reviewed journal featuring high-quality studies describing technological and operational advances in the production of biofuels, chemicals and other bioproducts. The journal emphasizes understanding and advancing the application of biotechnology and synergistic operations to improve plants and biological conversion systems for the biological production of these products from biomass, intermediates derived from biomass, or CO2, as well as upstream or downstream operations that are integral to biological conversion of biomass. Biotechnology for Biofuels focuses on the following areas: • Development of terrestrial plant feedstocks • Development of algal feedstocks • Biomass pretreatment, fractionation and extraction for biological conversion • Enzyme engineering, production and analysis • Bacterial genetics, physiology and metabolic engineering • Fungal/yeast genetics, physiology and metabolic engineering • Fermentation, biocatalytic conversion and reaction dynamics • Biological production of chemicals and bioproducts from biomass • Anaerobic digestion, biohydrogen and bioelectricity • Bioprocess integration, techno-economic analysis, modelling and policy • Life cycle assessment and environmental impact analysis