Draining Vein Thrombosis of Developmental Venous Anomaly in Sickle Cell Trait Patients: A Case Report and a Literature Review.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY

Pediatric Neurosurgery Pub Date : 2024-01-01 Epub Date: 2024-08-19 DOI:10.1159/000540929

Muhammed Amir Essibayi, Genesis Liriano, Kaitlin L Strumph, Deepa Manwani, Mandana Behbahani, David J Altschul

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引用次数: 0

Abstract

Introduction: Cerebral venous sinus thrombosis (CVST) is a rare but serious condition in both adults and children. Risk factors include thrombophilias, dehydration, and certain inherited conditions like sickle cell trait (SCT). We present a case of CVST in a pediatric patient with SCT to highlight key considerations in diagnosis and management.

Case presentation: A 14-year-old male with SCT presented with worsening headache and vomiting after prolonged sun exposure and dehydration during athletic camp. Imaging revealed right occipital hemorrhage, hydrocephalus, right CSVT, and bilateral cerebellar developmental venous anomalies. Hypercoagulability testing was normal. Diagnostic evaluation included computed tomography, magnetic resonance imaging, MR venography (MRV), and hypercoagulability testing. The patient was treated with an external ventricular drain, platelet transfusion, and anticoagulation. Management also involved hydration, platelet transfusion, supportive care, and multidisciplinary follow-up. Follow-up MRV showed recanalization.

Conclusion: This case highlights SCT as a potential CVST risk factor. Timely recognition, evaluation of precipitants like dehydration, supportive care including anticoagulation, and multidisciplinary management are important. An individualized approach is needed to balance thrombosis recurrence and bleeding risks. Patients with SCT require education on risks and prompt evaluation of neurological symptoms to allow early diagnosis and care of CVST.

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镰状细胞遗传患者发育性静脉异常引流静脉血栓：病例报告和文献综述。

简介脑静脉窦血栓形成（CVST）在成人和儿童中都是一种罕见但严重的疾病。危险因素包括血栓性疾病、脱水和某些遗传性疾病，如镰状细胞性状。我们介绍了一例镰状细胞性状儿科患者的 CVST 病例，以强调诊断和治疗中的关键注意事项：一名患有镰状细胞性状的 14 岁男性患者在运动训练营期间因长时间日晒和脱水而出现头痛和呕吐症状。影像学检查发现右枕部出血、脑积水、右侧 CSVT 和双侧小脑 DVA。高凝测试正常。诊断评估包括 CT、MRI、MRV 和高凝测试。患者接受了 EVD、血小板输注和抗凝治疗。治疗还包括水化、血小板输注、支持性护理和多学科随访。随访的 MRV 显示血管重新闭塞：本病例强调镰状细胞性状是潜在的 CVST 危险因素。及时识别、评估脱水等诱发因素、包括抗凝在内的支持性治疗和多学科管理非常重要。需要采取个体化的方法来平衡血栓复发和出血风险。SCT 患者需要接受风险教育并及时评估神经系统症状，以便及早诊断和治疗 CVST。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Neurosurgery 医学-临床神经学

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Articles in ''Pediatric Neurosurgery'' strives to publish new information and observations in pediatric neurosurgery and the allied fields of neurology, neuroradiology and neuropathology as they relate to the etiology of neurologic diseases and the operative care of affected patients. In addition to experimental and clinical studies, the journal presents critical reviews which provide the reader with an update on selected topics as well as case histories and reports on advances in methodology and technique. This thought-provoking focus encourages dissemination of information from neurosurgeons and neuroscientists around the world that will be of interest to clinicians and researchers concerned with pediatric, congenital, and developmental diseases of the nervous system.