Imetelstat: First Approval.

IF 13 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drugs Pub Date : 2024-09-01 Epub Date: 2024-08-20 DOI:10.1007/s40265-024-02080-x

Susan J Keam

引用次数: 0

Abstract

Imetelstat (RYTELO™), an oligonucleotide telomerase inhibitor, is being developed by Geron Corporation for the treatment of myeloid hematologic malignancies. In June 2024, imetelstat was approved in the USA for use in adult patients with low- to intermediate-1 risk myelodysplastic syndromes (MDS) with transfusion-dependent anemia requiring 4 or more red blood cell units over 8 weeks who have not responded to or have lost response to or are ineligible for erythropoiesis-stimulating agents (ESA). This article summarizes the milestones in the development of imetelstat leading to this first approval for the treatment of adult patients with low- to intermediate-1 risk MDS with transfusion-dependent anemia.

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伊美司他首次批准。

Imetelstat（RYTELO™）是一种寡核苷酸端粒酶抑制剂，由杰龙公司开发，用于治疗骨髓性血液恶性肿瘤。2024 年 6 月，依美司他在美国获批用于对红细胞生成刺激剂（ESA）无反应、失去反应或不符合条件的低至中 1 级风险骨髓增生异常综合征（MDS）伴输血依赖性贫血的成年患者，这些患者在 8 周内需要 4 个或更多红细胞单位。本文总结了依美司他开发过程中的里程碑事件，该药首次获批用于治疗伴有输血依赖性贫血的低至中1级风险MDS成人患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.