Lipiodol Versus Imipenem/Cilastatin in Genicular Artery Embolization: A Retrospective Study on Safety and Clinical Success.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

CardioVascular and Interventional Radiology Pub Date : 2024-12-01 Epub Date: 2024-08-19 DOI:10.1007/s00270-024-03836-4

Tevfik Guzelbey, Ali Dablan, Cagri Erdim, Rabia Deniz, Ilhan Nahit Mutlu, Ozgur Kilickesmez

{"title":"Lipiodol Versus Imipenem/Cilastatin in Genicular Artery Embolization: A Retrospective Study on Safety and Clinical Success.","authors":"Tevfik Guzelbey, Ali Dablan, Cagri Erdim, Rabia Deniz, Ilhan Nahit Mutlu, Ozgur Kilickesmez","doi":"10.1007/s00270-024-03836-4","DOIUrl":null,"url":null,"abstract":"Purpose: This study aims to evaluate the safety and effectiveness of genicular artery embolization (GAE) using lipiodol in comparison to imipenem/cilastatin (IPM-CS).Materials and methods: This retrospective study screened patients who underwent GAE between January 2022 and February 2023 for inclusion. Clinical outcomes were assessed at 1, 3, and 6 months post-procedure using the Visual Analog Scale (VAS) for pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for pain, stiffness, functional capacity, and total scores. Technical and clinical success rates, complications, and patient-reported outcomes were assessed.Results: A total of 42 patients were included in the study, with 13 patients treated with lipiodol and 29 with IPM-CS for GAE. Transient skin discoloration was noted in 23.1% of lipiodol patients and 31% of the IPM-CS group (p = 0.722). One patient (7.6%) in the lipiodol group developed knee edema and erythema due to drug-induced vasculitis (p = 0.309). Clinical success rates in the lipiodol group were 76.9% at 1 month, consistent at 3 months, and 69.2% at 6 months. For the IPM-CS group, success rates were 89.7, 86.2, and 75.9%, respectively, with no significant differences (p = 0.353, p = 0.657, p = 0.713). The median percentage change in WOMAC stiffness scores for the lipiodol group at 1, 3, and 6 months post-GAE were - 25%, - 16.7%, and - 16.7%, respectively, while the IPM-CS group showed decreases of - 40%, - 50%, and - 50%. Significant differences were found between the groups at all time points (p = 0.017, p = 0.009, and p = 0.002, respectively).Conclusion: Lipiodol shows comparable clinical success to IPM-CS in GAE.","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"1765-1773"},"PeriodicalIF":2.8000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CardioVascular and Interventional Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00270-024-03836-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This study aims to evaluate the safety and effectiveness of genicular artery embolization (GAE) using lipiodol in comparison to imipenem/cilastatin (IPM-CS).

Materials and methods: This retrospective study screened patients who underwent GAE between January 2022 and February 2023 for inclusion. Clinical outcomes were assessed at 1, 3, and 6 months post-procedure using the Visual Analog Scale (VAS) for pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for pain, stiffness, functional capacity, and total scores. Technical and clinical success rates, complications, and patient-reported outcomes were assessed.

Results: A total of 42 patients were included in the study, with 13 patients treated with lipiodol and 29 with IPM-CS for GAE. Transient skin discoloration was noted in 23.1% of lipiodol patients and 31% of the IPM-CS group (p = 0.722). One patient (7.6%) in the lipiodol group developed knee edema and erythema due to drug-induced vasculitis (p = 0.309). Clinical success rates in the lipiodol group were 76.9% at 1 month, consistent at 3 months, and 69.2% at 6 months. For the IPM-CS group, success rates were 89.7, 86.2, and 75.9%, respectively, with no significant differences (p = 0.353, p = 0.657, p = 0.713). The median percentage change in WOMAC stiffness scores for the lipiodol group at 1, 3, and 6 months post-GAE were - 25%, - 16.7%, and - 16.7%, respectively, while the IPM-CS group showed decreases of - 40%, - 50%, and - 50%. Significant differences were found between the groups at all time points (p = 0.017, p = 0.009, and p = 0.002, respectively).

Conclusion: Lipiodol shows comparable clinical success to IPM-CS in GAE.

Abstract Image

查看原文本刊更多论文

利必多与亚胺培南/西司他丁在膝关节动脉栓塞术中的对比：关于安全性和临床成功率的回顾性研究

目的：本研究旨在评估与亚胺培南/西司他丁（IPM-CS）相比，使用脂碘的膝状动脉栓塞术（GAE）的安全性和有效性：这项回顾性研究筛选了2022年1月至2023年2月期间接受GAE的患者。使用视觉模拟量表（VAS）评估术后1、3和6个月的临床结果，使用西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评估疼痛、僵硬度、功能能力和总分。对技术和临床成功率、并发症以及患者报告的结果进行了评估：共有 42 名患者参与了研究，其中 13 名患者接受了脂肪碘治疗，29 名患者接受了 IPM-CS 治疗 GAE。23.1%的脂肪碘患者和31%的 IPM-CS 组患者出现短暂的皮肤变色（p = 0.722）。脂碘醇组（7.6%）的一名患者因药物诱发脉管炎而出现膝盖水肿和红斑（p = 0.309）。脂碘醇组 1 个月的临床成功率为 76.9%，3 个月的临床成功率一致，6 个月的临床成功率为 69.2%。IPM-CS 组的成功率分别为 89.7%、86.2% 和 75.9%，无显著差异（p = 0.353、p = 0.657、p = 0.713）。GAE后1个月、3个月和6个月时，脂肪碘醇组的WOMAC僵硬度评分变化百分比中位数分别为-25%、-16.7%和-16.7%，而IPM-CS组则分别下降了-40%、-50%和-50%。各组在所有时间点上均存在显著差异（分别为 p = 0.017、p = 0.009 和 p = 0.002）：结论：在 GAE 中，利必多的临床疗效与 IPM-CS 相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

CardioVascular and Interventional Radiology 医学-核医学

CiteScore

5.50

自引率

13.80%

发文量

306

审稿时长

3-8 weeks

期刊介绍： CardioVascular and Interventional Radiology (CVIR) is the official journal of the Cardiovascular and Interventional Radiological Society of Europe, and is also the official organ of a number of additional distinguished national and international interventional radiological societies. CVIR publishes double blinded peer-reviewed original research work including clinical and laboratory investigations, technical notes, case reports, works in progress, and letters to the editor, as well as review articles, pictorial essays, editorials, and special invited submissions in the field of vascular and interventional radiology. Beside the communication of the latest research results in this field, it is also the aim of CVIR to support continuous medical education. Articles that are accepted for publication are done so with the understanding that they, or their substantive contents, have not been and will not be submitted to any other publication.