Recent advancement in developing small molecular inhibitors targeting key kinase pathways against triple-negative breast cancer

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry Pub Date : 2024-08-18 DOI:10.1016/j.bmc.2024.117877

Rajibul Islam , Khor Poh Yen , Nur Najihah ’Izzati Mat Rani , Md. Selim Hossain

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Abstract

Triple-negative breast cancer (TNBC) stands out as the most formidable variant of breast cancer, predominantly affecting younger women and characterized by a bleak outlook and a high likelihood of spreading. The absence of safe and effective targeted treatments leaves standard cytotoxic chemotherapy as the primary option. The role of protein kinases, frequently altered in many cancers, is significant in the advancement and drug resistance of TNBC, making them a logical target for creating new, potent therapies against TNBC. Recently, an array of promising small molecules aimed at various kinases have been developed specifically for TNBC, with combination studies showing a synergistic improvement in combatting this condition. This review underscores the effectiveness of small molecule kinase inhibitors in battling the most lethal form of breast cancer and sheds light on prospective pathways for crafting novel treatments.

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针对三阴性乳腺癌关键激酶通路开发小分子抑制剂的最新进展

三阴性乳腺癌（TNBC）是最可怕的乳腺癌变种，主要影响年轻女性，其特点是前景暗淡且极易扩散。由于缺乏安全有效的靶向治疗，标准的细胞毒化疗成为主要选择。蛋白激酶在许多癌症中经常发生变化，在 TNBC 的发展和耐药性方面起着重要作用，因此蛋白激酶是开发针对 TNBC 的新型强效疗法的合理靶点。最近，一系列针对各种激酶的前景看好的小分子药物已被开发出来，专门用于 TNBC。这篇综述强调了小分子激酶抑制剂在对抗最致命的乳腺癌方面的有效性，并揭示了开发新型疗法的前瞻性途径。

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来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.