The effect of vitamin D2 on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans: A systematic review and meta-analysis of randomized controlled trials

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-21 DOI:10.1016/j.prostaglandins.2024.106883

Zhihong Zhou , Jiyuan Liu , Hui Zhang , Kousalya Prabahar , Benjamin Hernández-Wolters , Yuanhong Yuan

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引用次数: 0

Abstract

Background and aim

Even though the role of D2 (ergocalciferol) on cardiovascular disease risk components has been studied, conflicting results have been reported. Moreover, no single study has studied all these parameters and the role of vitamin D2 individually has not been assessed; hence, this systematic review and meta-analysis of randomized controlled trials was conducted to assess the effect of vitamin D2 supplementation on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans.

Methods

Web of Science, Scopus, PubMed/Medline, and Embase were searched from database inception to July 2024, and the random effects model, according to the DerSimonian and Laird method, was used to generate combined estimates of the intervention’s effect on the outcomes.

Results

After full-text analysis, 11 eligible articles were included in our meta-analyses. No statistically significant association was observed between vitamin D2 administration and BMI, WC, TC, HDL-C, LDL-C, TG, DBP or SBP; however, a statistically significant decrease in CRP (WMD: − 1.92 mg/dL, 95 % CI: − 3.30 to − 0.54, P = 0.006) and HbA1c levels (WMD: − 0.37 %, 95 % CI: − 0.66 to − 0.09, P = 0.009), and a non-statistically significant decrease in FBG (WMD: − 4.61 mg/dL, 95 % CI: − 14.71 to 5.47, P = 0.370, I2 = 90 %, P ˂ 0.001) and HOMA-IR (WMD: − 0.10, 95 % CI: − 0.17–0.03, P = 0.002) were detected.

Conclusion

In summary, our systematic review and meta-analysis discovered that vitamin D2 administration was associated with a statistically significant decrease in CRP and HbA1c levels, without a significant correlation with other outcomes.

查看原文本刊更多论文

维生素 D2 对人体血脂概况、人体测量指数、血压以及炎症和血糖生物标志物的影响：随机对照试验的系统回顾和荟萃分析。

背景和目的：尽管已经对 D2（麦角钙化醇）对心血管疾病风险成分的作用进行了研究，但报告的结果相互矛盾。因此，本研究对随机对照试验进行了系统回顾和荟萃分析，以评估补充维生素 D2 对人体血脂、人体测量指数、血压、炎症和血糖生物标志物的影响：方法：检索了从数据库开始到 2024 年 7 月的 Web of Science、Scopus、PubMed/Medline 和 Embase，并根据 DerSimonian 和 Laird 方法使用随机效应模型得出干预对结果影响的综合估计值：经过全文分析，11 篇符合条件的文章被纳入荟萃分析。在服用维生素 D2 与 BMI、WC、TC、HDL-C、LDL-C、TG、DBP 或 SBP 之间未观察到有统计学意义的关联；然而，CRP（WMD：-1.92mg/dL，95% CI：-3.30 至 -0.54，P= 0.006）和 HbA1c 水平（WMD：-0.37%，95% CI：-0.66 至 -0.09，P= 0.009），FBG（WMD：-4.61mg/dL，95% CI：-14.71 至 5.47，P= 0.370，I2=90%，P˂0.001）和 HOMA-IR （WMD：-0.10，95% CI：-0.17 至 0.03，P= 0.002）出现非统计学显著下降：总之，我们的系统综述和荟萃分析发现，服用维生素 D2 与 CRP 和 HbA1c 水平的统计学显著下降有关，但与其他结果无显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464