Research progress on the role of gut microbiota and its metabolites in the occurrence and development of septic-associated liver injury.

IF 2.7 3区医学 Q2 CRITICAL CARE MEDICINE

SHOCK Pub Date : 2024-08-14 DOI:10.1097/SHK.0000000000002441

Jiangtao Chen, Y U Song, Wenqing Zeng, Lei Wang, Jinyan Qin, Lexin Fang, Yueping Ding

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Abstract

Abstract: Sepsis is a life-threatening organ dysfunction that occurs due to a dysregulated host response to infection. Septic-associated liver injury (SALI) has been closely linked to the prognosis and mortality of sepsis. Recent investigations have delved into the gut-liver axis and its association with SALI, identifying its pivotal role in the gut microbiota. Bacterial translocation and the onset of SALI can occur due to an imbalance in the gut microbiota, impairing the function of the gut barrier. Moreover, their metabolites might exacerbate or initiate SALI by modulating immune responses. Nevertheless, interventions to restore the balance of the gut microbiota, such as the administration of probiotics, fecal microbiota transplantation, or dietary adjustments, may ameliorate SALI and enhance the prognosis and survival rates of septic patients. This review aimed to elucidate the function of the gut microbiota in the genesis and procession of SALI and its potential therapeutic value, offering a deeper understanding of the pathogenesis and therapeutic avenues for SALI.

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关于肠道微生物群及其代谢物在脓毒症相关肝损伤的发生和发展中的作用的研究进展。

摘要：败血症是由于宿主对感染的反应失调而导致的危及生命的器官功能障碍。败血症相关性肝损伤（SALI）与败血症的预后和死亡率密切相关。最近的研究深入探讨了肠道-肝脏轴及其与 SALI 的关系，确定了其在肠道微生物群中的关键作用。细菌转运和 SALI 的发生可能是由于肠道微生物群失衡，损害了肠道屏障的功能。此外，它们的代谢产物可能会通过调节免疫反应而加剧或引发 SALI。然而，恢复肠道微生物群平衡的干预措施，如服用益生菌、粪便微生物群移植或饮食调整，可改善 SALI 并提高败血症患者的预后和存活率。本综述旨在阐明肠道微生物群在 SALI 发生和发展过程中的功能及其潜在的治疗价值，从而加深对 SALI 发病机制和治疗途径的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

SHOCK 医学-外科

CiteScore

6.20

自引率

3.20%

发文量

199

审稿时长

1 months

期刊介绍： SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches includes studies of novel therapeutic approaches, such as immunomodulation, gene therapy, nutrition, and others. The mission of the Journal is to foster and promote multidisciplinary studies, both experimental and clinical in nature, that critically examine the etiology, mechanisms and novel therapeutics of shock-related pathophysiological conditions. Its purpose is to excel as a vehicle for timely publication in the areas of basic and clinical studies of shock, trauma, sepsis, inflammation, ischemia, and related pathobiological states, with particular emphasis on the biologic mechanisms that determine the response to such injury. Making such information available will ultimately facilitate improved care of the traumatized or septic individual.