Evaluating 64Cu-DOTA-rituximab as a PET agent in patients with B-cell lymphoma: a head-to-head comparison with 18F-fluorodeoxyglucose PET/computed tomography.

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Inki Lee, Byung Hyun Byun, Byung Il Kim, Chang Woon Choi, Hye Jin Kang, Chi Soo Kang, Sang-Keun Woo, Kyo Chul Lee, Joo Hyun Kang, Ilhan Lim
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引用次数: 0

Abstract

Background: This study aimed to evaluate the biodistribution of 64Cu-DOTA-rituximab and its diagnostic feasibility for lymphoma using CD20-targeted 64Cu-DOTA-rituximab PET/computed tomography (PET/CT).

Methods: A prospective study involving six patients diagnosed with lymphoma was conducted between January 2022 and January 2023. These patients underwent 18F-fluorodeoxyglucose (18F-FDG) and 64Cu-DOTA-rituximab PET/CT scans. 64Cu-DOTA-rituximab PET/CT images were acquired at 1, 24, and 48 h after administering 64Cu-DOTA-rituximab to assess the biodistribution and dosimetry over time. The observed lymph nodes were categorized into specific regions, including cervical and supraclavicular, axillary and infraclavicular, mediastinal, hilar, abdominal paraaortic and retroperitoneal, iliac, mesenteric, and inguinal regions, to compare the diagnostic ability of 18F-FDG and 64Cu-DOTA-rituximab PET/CT in detecting lymphoma lesions. Furthermore, the tumor-to-background ratio was calculated and compared with the maximum standardized uptake (SUVmax) of the tumors and the mean standardized uptake (SUVmean) of normal organs. Internal radiation dosimetry was determined using the OLINDA/EXM software.

Results: 64Cu-DOTA-rituximab uptake in lymph nodes associated with lymphoma progressively increased from 1 to 48 h after injection. In contrast, 64Cu-DOTA-rituximab uptake in normal organs, such as blood, lung, kidney, bladder, muscle, bone, and brain, decreased over time, whereas it increased in the liver and spleen. When it comes to the comparison between 64Cu-DOTA-rituximab and 18F-FDG, the SUVmax of tumors was higher on 64Cu-DOTA-rituximab PET/CT (18.1 ± 8.3) than on 18F-FDG PET/CT (5.2 ± 1.5). Additionally, the tumor-to-background ratio, measured using the SUVmean of normal muscles, was higher on 64Cu-DOTA-rituximab PET/CT (55.7 ± 31.0) than on 18F-FDG PET/CT (8.6 ± 2.8). No adverse events related to 64Cu-DOTA-rituximab injection were reported.

Conclusion: The results of this study demonstrate the feasibility of using 64Cu-DOTA-rituximab PET/CT to evaluate the CD20 expression. The increased 64Cu-DOTA-rituximab uptake in lymph nodes associated with tumors, higher SUVmax, and tumor-to-muscle ratios observed with 64Cu-DOTA-rituximab PET/CT compared with 18F-FDG PET/CT, highlight the diagnostic potential of this imaging modality.

将 64Cu-DOTA-rituximab 作为 B 细胞淋巴瘤患者的 PET 剂进行评估:与 18F 氟脱氧葡萄糖 PET/计算机断层扫描的正面比较。
研究背景本研究旨在评估64Cu-DOTA-利妥昔单抗的生物分布以及使用CD20靶向64Cu-DOTA-利妥昔单抗PET/计算机断层扫描(PET/CT)诊断淋巴瘤的可行性:2022年1月至2023年1月期间进行了一项前瞻性研究,涉及6名确诊为淋巴瘤的患者。这些患者接受了 18F- 氟脱氧葡萄糖(18F-FDG)和 64Cu-DOTA-rituximab PET/CT 扫描。64Cu-DOTA-rituximab PET/CT 图像是在注射 64Cu-DOTA-rituximab 后 1、24 和 48 小时采集的,用于评估生物分布和剂量随时间变化的情况。观察到的淋巴结按特定区域分类,包括颈部和锁骨上、腋窝和锁骨下、纵隔、腹股沟、腹主动脉旁和腹膜后、髂骨、肠系膜和腹股沟区域,以比较 18F-FDG 和 64Cu-DOTA-rituximab PET/CT 检测淋巴瘤病变的诊断能力。此外,还计算了肿瘤与背景的比率,并与肿瘤的最大标准化摄取量(SUVmax)和正常器官的平均标准化摄取量(SUVmean)进行了比较。使用 OLINDA/EXM 软件确定内部辐射剂量:结果:64Cu-DOTA-利妥昔单抗在淋巴瘤相关淋巴结中的摄取量在注射后1至48小时内逐渐增加。相比之下,64Cu-DOTA-利妥昔单抗在血液、肺、肾、膀胱、肌肉、骨和脑等正常器官中的摄取量随着时间的推移而降低,而在肝脏和脾脏中的摄取量则有所增加。64Cu-DOTA-利妥昔单抗与 18F-FDG 相比,64Cu-DOTA-利妥昔单抗 PET/CT 的肿瘤 SUVmax(18.1 ± 8.3)高于 18F-FDG PET/CT(5.2 ± 1.5)。此外,使用正常肌肉的 SUVmean 值测量的肿瘤与背景比值在 64Cu-DOTA-rituximab PET/CT 上(55.7 ± 31.0)高于 18F-FDG PET/CT (8.6 ± 2.8)。没有与注射 64Cu-DOTA-rituximab 相关的不良事件报告:本研究结果证明了使用 64Cu-DOTA-rituximab PET/CT 评估 CD20 表达的可行性。与 18F-FDG PET/CT 相比,64Cu-DOTA-利妥昔单抗 PET/CT 观察到与肿瘤相关的淋巴结对 64Cu-DOTA-rituximab 的摄取增加、SUVmax 增加以及肿瘤与肌肉的比率增加,这凸显了这种成像方式的诊断潜力。
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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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