Assessment of renal perfusion with 82-rubidium PET in patients with normal and abnormal renal function.

IF 1.3 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuclear Medicine Communications Pub Date : 2024-08-19 DOI:10.1097/MNM.0000000000001890

Alexandre Bibeau-Delisle, Nadia Bouabdallaoui, Caroline Lamarche, Francois Harel, Matthieu Pelletier-Galarneau

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引用次数: 0

Abstract

Background: Noninvasive measurement of renal blood flow (RBF) and renal vascular resistance (RVR) is challenging, yet critical in renal pathologies. This study evaluates the correlation between serum renal function markers and RBF/RVR assessed using rubidium PET.

Methods: Dynamic images from 53 patients who underwent rubidium PET for nonrenal indications were analyzed. RBF was determined using a one-compartment model, and RVR was calculated by dividing mean arterial pressure by RBF.

Results: The study included 51 patients (31 females and 20 males). Among them, 35 had normal renal function [estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2], and 16 had abnormal renal function (eGFR <60 ml/min/1.73 m2). Patients with normal renal function had significantly higher RBF [median (interquartile range): 443 (297-722) vs 173 (108-380) ml/min/100 g, P = 0.022] and lower RVR [19.1 (12.4-27.2) vs 49.6 (24.4-85.7) mmHg×min×g/ml, P = 0.0011) compared with those with abnormal renal function. There was a moderate correlation between RBF and eGFR (r = 0.62, P < 0.0001) and between RVR and eGFR (r = -0.59, P < 0.0001) in both groups. Among patients with normal renal function, RBF was negatively correlated with age (r = -0.51, P = 0.0017) but there was no correlation among patients with abnormal renal function (r = 0.21, P = 0.44).

Conclusion: PET-measured RBF and RVR correlate with renal function markers and differ significantly by renal function status. Further studies are needed to validate rubidium PET's precision and clinical applicability.

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用 82 铷正电子发射计算机断层成像技术评估肾功能正常和异常患者的肾脏灌注情况。

背景：肾血流（RBF）和肾血管阻力（RVR）的无创测量具有挑战性，但对肾脏病变却至关重要。本研究评估了血清肾功能标记物与使用铷正电子发射计算机断层显像技术评估的 RBF/RVR 之间的相关性：方法：分析了 53 例因非肾脏疾病接受铷正电子发射计算机断层显像的患者的动态图像。采用单室模型确定 RBF，用平均动脉压除以 RBF 计算 RVR：研究共纳入 51 名患者（31 名女性和 20 名男性）。其中 35 人肾功能正常[估计肾小球滤过率（eGFR）≥60 ml/min/1.73 m2]，16 人肾功能异常（eGFR 结论）：PET 测量的 RBF 和 RVR 与肾功能标志物相关，并因肾功能状态而有显著差异。还需要进一步的研究来验证铷PET的精确性和临床适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Medicine Communications 医学-核医学

CiteScore

2.20

自引率

6.70%

发文量

212

审稿时长

3-8 weeks

期刊介绍： Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.

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