Erythrocyte deformability correlates with systemic inflammation

IF 2.1 4区 医学 Q3 HEMATOLOGY
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引用次数: 0

Abstract

Recent evidence suggests that systemic conditions, particularly those associated with inflammation, can affect erythrocyte deformability in the absence of haematological conditions. In this exploratory study, we investigated the relationship between systemic inflammatory status and erythrocyte deformability (using osmotic gradient ektacytometry) in a heterogenous study population consisting of individuals with no medical concerns, chronic conditions, and acute illness, providing a wide range of systemic inflammation severity.

22 participants were included in a prospective observational study. Maximum Elongation Index (EImax) in ektacytometry served as the readout for erythrocyte deformability. Inflammatory status was assessed using C-reactive protein (CRP) and self-reported symptoms associated with inflammatory activation (Sickness Questionnaire Scores, SicknessQ).

In a univariate linear regression, both CRP and SicknessQ scores significantly predicted EImax (CRP: F(1,20) = 7.751, p < 0.05 (0.011), R2 = 0.279; SicknessQ: F(1,18) = 4.831, p < 0.05 (0.041), R2 = 0.212). Sensitivity analyses with multivariable linear regression correcting for age showed concordant findings.

Results suggest a linear relationship between erythrocyte deformability and biochemical and clinical markers of systemic inflammation. Replication of findings in a larger study, and mechanisms and clinical consequences need further in investigation.

红细胞变形性与全身炎症相关
最近的证据表明,全身性疾病,尤其是与炎症相关的疾病,会在没有血液病的情况下影响红细胞的变形性。在这项探索性研究中,我们调查了系统性炎症状态与红细胞变形性之间的关系(使用渗透梯度红细胞计数法),研究对象是由无病症、慢性病和急性病患者组成的异质性研究人群,提供了广泛的系统性炎症严重程度。红细胞最大伸长指数(EImax)是红细胞变形性的读数。炎症状态通过 C 反应蛋白(CRP)和与炎症激活相关的自我报告症状(疾病问卷评分,SicknessQ)进行评估。在单变量线性回归中,CRP 和 SicknessQ 评分均可显著预测 EImax(CRP:F(1,20) = 7.751,p < 0.05 (0.011),R2 = 0.279;SicknessQ:F(1,18) = 4.831,p < 0.05 (0.041),R2 = 0.212)。结果表明,红细胞变形性与全身炎症的生化和临床指标之间存在线性关系。研究结果表明,红细胞变形性与全身炎症的生化和临床指标之间存在线性关系。
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来源期刊
CiteScore
4.90
自引率
0.00%
发文量
42
审稿时长
14 days
期刊介绍: Blood Cells, Molecules & Diseases emphasizes not only blood cells, but also covers the molecular basis of hematologic disease and studies of the diseases themselves. This is an invaluable resource to all those interested in the study of hematology, cell biology, immunology, and human genetics.
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