Lack of genetic association of non-melanoma skin cancer and pseudoexfoliative glaucoma.

IF 1.2 4区医学 Q4 GENETICS & HEREDITY

Ophthalmic Genetics Pub Date : 2024-08-15 DOI:10.1080/13816810.2024.2390008

Alice A Beneke, Jon D Wiese, Kevin T Root, Kamil Taneja, Casey J Beal

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引用次数: 0

Abstract

Background: Prior research has shown a positive association of pseudoexfoliative glaucoma (PXG) in patients with non-melanoma skin cancer (NMSC), likely due to an increase in ultraviolet exposure associated with both. However, the role of NMSC as a genetic risk factor for PXG has not been examined. Thus, the goal of this study is to utilize Mendelian randomization with genome-wide association studies to evaluate for genetic causality while controlling for environmental confounders.

Methods: We conducted a MR using the inverse variance weighted method (MR-IVW) as our primary analysis. Genomic data was sourced from GWASs for patients with NMSC (10,382 cases, 208,410 controls) and PXG (1,515 cases and 210,201 controls), originating from the FinnGen Biobank.

Results: Despite previous association of history of NMSC with occurrence of PXG, we found no evidence for a causal association between SNPs associated with NMSC and risk of PXG following MR analysis (MR-IVW, odds ratio (OR): 0.98, 95% CI: 0.85-1.14, P = 0.87).

Conclusion: Here, we found no evidence for a causal association between SNPs associated with NMSC and the risk of PXG following a MR analysis.

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非黑色素瘤皮肤癌与假性外叶性青光眼缺乏遗传关联。

背景：先前的研究表明，假性角膜外剥脱性青光眼（PXG）与非黑色素瘤皮肤癌（NMSC）患者呈正相关，这可能是由于两者都会增加紫外线照射所致。然而，NMSC 作为 PXG 遗传风险因素的作用尚未得到研究。因此，本研究的目标是利用孟德尔随机化与全基因组关联研究来评估遗传因果关系，同时控制环境混杂因素：方法：我们使用反方差加权法（MR-IVW）进行了一次 MR 作为主要分析。基因组数据来源于芬兰基因生物库（FinnGen Biobank）中关于NMSC患者（10382例，208410例对照）和PXG患者（1515例，210201例对照）的GWAS：结果：尽管之前发现 NMSC 病史与 PXG 的发生有关，但通过 MR 分析（MR-IVW，几率比（OR）：0.98，95% CI：0.85-1.14，P = 0.87），我们没有发现证据表明与 NMSC 相关的 SNPs 与 PXG 风险之间存在因果关系：在此，我们没有发现与 NMSC 相关的 SNPs 与 MR 分析后的 PXG 风险之间存在因果关系的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic Genetics 医学-眼科学

CiteScore

2.40

自引率

8.30%

发文量

126

审稿时长

>12 weeks

期刊介绍： Ophthalmic Genetics accepts original papers, review articles and short communications on the clinical and molecular genetic aspects of ocular diseases.