Metabolomics and cellular altered pathways in cancer biology: A review

IF 3.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biochemical and Molecular Toxicology Pub Date : 2024-08-15 DOI:10.1002/jbt.23807

Jitender Kumar Bhardwaj, Anshu Siwach, Som Nath Sachdeva

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Abstract

Cancer is a deadly disease that affects a cell's metabolism and surrounding tissues. Understanding the fundamental mechanisms of metabolic alterations in cancer cells would assist in developing cancer treatment targets and approaches. From this perspective, metabolomics is a great analytical tool to clarify the mechanisms of cancer therapy as well as a useful tool to investigate cancer from a distinct viewpoint. It is a powerful emerging technology that detects up to thousands of molecules in tissues and biofluids. Like other “-omics” technologies, metabolomics involves the comprehensive investigation of micromolecule metabolites and can reveal important details about the cancer state that is otherwise not apparent. Recent developments in metabolomics technologies have made it possible to investigate cancer metabolism in greater depth and comprehend how cancer cells utilize metabolic pathways to make the amino acids, nucleotides, and lipids required for tumorigenesis. These new technologies have made it possible to learn more about cancer metabolism. Here, we review the cellular and systemic effects of cancer and cancer treatments on metabolism. The current study provides an overview of metabolomics, emphasizing the current technologies and their use in clinical and translational research settings.

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癌症生物学中的代谢组学和细胞改变途径：综述。

癌症是一种影响细胞代谢和周围组织的致命疾病。了解癌细胞代谢改变的基本机制有助于开发癌症治疗目标和方法。从这个角度来看，代谢组学是阐明癌症治疗机制的重要分析工具，也是从不同角度研究癌症的有用工具。它是一种强大的新兴技术，可检测组织和生物流体中多达数千种分子。与其他"-组学 "技术一样，代谢组学涉及对微观分子代谢物的全面研究，可以揭示癌症状态的重要细节。代谢组学技术的最新发展使人们有可能更深入地研究癌症代谢，了解癌细胞如何利用代谢途径制造肿瘤发生所需的氨基酸、核苷酸和脂质。这些新技术使我们有可能更多地了解癌症代谢。在此，我们回顾了癌症和癌症治疗对新陈代谢的细胞和全身影响。本研究概述了代谢组学，强调了当前的技术及其在临床和转化研究中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biochemical and Molecular Toxicology 生物-毒理学

CiteScore

5.80

自引率

2.80%

发文量

277

审稿时长

6-12 weeks

期刊介绍： The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.