New Drugs for Targeted Radionuclide Therapy in Metastatic Prostate Cancer

IF 4.8 2区医学 Q1 UROLOGY & NEPHROLOGY

European urology focus Pub Date : 2024-07-01 DOI:10.1016/j.euf.2024.07.016

Kévin Hébert , Paul Bodin-Cufi , Cyril Fersing , Emmanuel Deshayes

引用次数: 0

Abstract

Metastatic prostate cancer is a frequent and fatal disease. Targeted radionuclide therapy (TRT) has become a readily available therapeutic option since the approval of [¹⁷⁷Lu]Lu-PSMA-617. Various molecules are currently being studied for TRT in prostate cancer. We review various combinations of isotopes and vectors being used to target prostate cancer cells and optimize pharmacokinetics. Promising innovations include chemical modifications to improve biodistribution, identification of new targets, and the use of novel radioisotopes such as α emitters.

Patient summary

Our mini review summarizes research on targeted radioactive drugs for treatment of metastatic prostate cancer. Several promising radioactive pharmaceuticals are being evaluated in clinical trials, but more studies are necessary before these can be used in routine clinical practice.

查看原文本刊更多论文

用于转移性前列腺癌放射性核素靶向治疗的新药。

转移性前列腺癌是一种常见的致命疾病。自[177Lu]Lu-PSMA-617获批以来，靶向放射性核素治疗（TRT）已成为一种现成的治疗方法。目前正在研究用于前列腺癌 TRT 的各种分子。我们回顾了用于靶向前列腺癌细胞和优化药代动力学的同位素和载体的各种组合。有前景的创新包括改善生物分布的化学修饰、新靶点的确定以及新型放射性同位素（如α发射体）的使用。患者摘要：我们的微型综述总结了治疗转移性前列腺癌的靶向放射性药物研究。目前正在对几种前景看好的放射性药物进行临床试验评估，但在将这些药物用于常规临床实践之前，还需要进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European urology focus Medicine-Urology

CiteScore

10.40

自引率

3.70%

发文量

274

审稿时长

23 days

期刊介绍： European Urology Focus is a new sister journal to European Urology and an official publication of the European Association of Urology (EAU). EU Focus will publish original articles, opinion piece editorials and topical reviews on a wide range of urological issues such as oncology, functional urology, reconstructive urology, laparoscopy, robotic surgery, endourology, female urology, andrology, paediatric urology and sexual medicine. The editorial team welcome basic and translational research articles in the field of urological diseases. Authors may be solicited by the Editor directly. All submitted manuscripts will be peer-reviewed by a panel of experts before being considered for publication.