The effects of drone transportation on routine laboratory, immunohematology, flow cytometry and molecular analyses.

IF 3.8 2区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Steven Weekx, Philippe Van Lint, Sam Jacobs
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Abstract

Objectives: Transportation of medical samples between laboratories or hospital sites is typically performed by motorized ground transport. Due to the increased traffic congestions in urban environments, drone transportation has become an attractive alternative for fast shipping of samples. In accordance with the CLSI guidelines and the ISO 15189 standard, the impact of this transportation type on sample integrity and performance of laboratory tests must be thoroughly validated.

Methods: Blood samples from 36 healthy volunteers and bacterial spiked urine samples were subjected to a 20-40 min drone flight before they were analyzed and compared with their counterparts that stayed on the ground. Effects on stability of 30 routine biochemical and hematological parameters, immunohematology tests and flow cytometry and molecular tests were evaluated.

Results: No clinically relevant effects on blood group typing, flow cytometry lymphocyte subset testing and on the stability of the multicopy opacity-associated proteins (Opa) genes in bacterial DNA nor on the number of Abelson murine leukemia viral oncogene homolog 1 (abl) housekeeping genes in human peripheral blood cells were seen. For three of the 30 biochemistry and hematology parameters a statistically significant difference was found: gamma-glutamyl transferase (gamma-GT), mean corpuscular hemoglobin (MCH) and thrombocyte count. A clinically relevant effect however was only seen for potassium and lactate dehydrogenase (LDH).

Conclusions: Multi-rotor drone transportation can be used for medical sample transportation with no effect on the majority of the tested parameters, including flow cytometry and molecular analyses, with the exception of a limited clinical impact on potassium and LDH.

无人机运输对常规实验室、免疫血液学、流式细胞术和分子分析的影响。
目的:实验室或医院之间的医疗样本运输通常采用机动地面运输方式。由于城市交通拥堵加剧,无人机运输已成为快速运送样本的一种有吸引力的替代方式。根据 CLSI 指南和 ISO 15189 标准,必须彻底验证这种运输方式对样本完整性和实验室测试性能的影响:方法:对 36 名健康志愿者的血液样本和添加细菌的尿液样本进行 20-40 分钟的无人机飞行后再进行分析,并与地面上的样本进行比较。评估了无人机飞行对 30 项常规生化和血液学参数、免疫血液学检测、流式细胞术和分子检测的稳定性的影响:结果:对血型分型、流式细胞仪淋巴细胞亚群检测、细菌 DNA 中多拷贝不透明相关蛋白(Opa)基因的稳定性以及人类外周血细胞中阿贝尔森鼠白血病病毒癌基因同源物 1(abl)看家基因的数量均未发现任何临床相关影响。在 30 项生物化学和血液学参数中,有 3 项在统计学上有显著差异:γ-谷氨酰转移酶(γ-GT)、平均血红蛋白(MCH)和血小板计数。但只有钾和乳酸脱氢酶(LDH)具有临床相关性:结论:多旋翼无人机运输可用于医疗样本运输,对大多数测试参数(包括流式细胞术和分子分析)没有影响,但对血钾和乳酸脱氢酶的临床影响有限。
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来源期刊
Clinical chemistry and laboratory medicine
Clinical chemistry and laboratory medicine 医学-医学实验技术
CiteScore
11.30
自引率
16.20%
发文量
306
审稿时长
3 months
期刊介绍: Clinical Chemistry and Laboratory Medicine (CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor over 3. CCLM is issued monthly, and it is published in print and electronically. CCLM is the official journal of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and publishes regularly EFLM recommendations and news. CCLM is the official journal of the National Societies from Austria (ÖGLMKC); Belgium (RBSLM); Germany (DGKL); Hungary (MLDT); Ireland (ACBI); Italy (SIBioC); Portugal (SPML); and Slovenia (SZKK); and it is affiliated to AACB (Australia) and SFBC (France). Topics: - clinical biochemistry - clinical genomics and molecular biology - clinical haematology and coagulation - clinical immunology and autoimmunity - clinical microbiology - drug monitoring and analysis - evaluation of diagnostic biomarkers - disease-oriented topics (cardiovascular disease, cancer diagnostics, diabetes) - new reagents, instrumentation and technologies - new methodologies - reference materials and methods - reference values and decision limits - quality and safety in laboratory medicine - translational laboratory medicine - clinical metrology Follow @cclm_degruyter on Twitter!
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