Aika Yokoyama, Hanami Aoki, Mizuki Funayama, Ryo Shinozaki, Hiroto Yoshida, Dr. Akinobu Z. Suzuki, Prof. Dr. Toshiaki Furuta
{"title":"Front Cover: Design, Synthesis, and Photochemical Properties of Gene-directed Caged RyR Probes for Photopharmacological Studies (ChemPhotoChem 8/2024)","authors":"Aika Yokoyama, Hanami Aoki, Mizuki Funayama, Ryo Shinozaki, Hiroto Yoshida, Dr. Akinobu Z. Suzuki, Prof. Dr. Toshiaki Furuta","doi":"10.1002/cptc.202480801","DOIUrl":null,"url":null,"abstract":"<p><b>The Front Cover</b> illustrates the molecular structures of coumarin-caged ryanodine receptor (RyR) agonists and blockers. Photo-irradiation of a (6-bromo-7-hydroxycoumarin-4-yl)methyl (Bhc)-caged agonist released the active form, activated RyRs, and promoted Ca<sup>2+</sup> release from the <i>endoplasmic reticulum</i> in mammalian cells. The photoreactivity of the caged RyR probes by 405 nm light was masked by the enzyme substrates, allowing cell-type-selective, enzyme gene-directed delivery of the caged RyR probes. More information can be found in the Research Article by A. Yokoyama, H. Aoki, T. Furuta et al. (DOI 10.1002/cptc.202400140).<figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":10108,"journal":{"name":"ChemPhotoChem","volume":"8 8","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cptc.202480801","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemPhotoChem","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cptc.202480801","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The Front Cover illustrates the molecular structures of coumarin-caged ryanodine receptor (RyR) agonists and blockers. Photo-irradiation of a (6-bromo-7-hydroxycoumarin-4-yl)methyl (Bhc)-caged agonist released the active form, activated RyRs, and promoted Ca2+ release from the endoplasmic reticulum in mammalian cells. The photoreactivity of the caged RyR probes by 405 nm light was masked by the enzyme substrates, allowing cell-type-selective, enzyme gene-directed delivery of the caged RyR probes. More information can be found in the Research Article by A. Yokoyama, H. Aoki, T. Furuta et al. (DOI 10.1002/cptc.202400140).
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
