The role of hydrogen sulfide in the regulation of necroptosis across various pathological processes.

Abstract

Necroptosis is a programmed cell death form executed by receptor-interacting protein kinase (RIPK) 1, RIPK3 and mixed lineage kinase domain-like protein (MLKL), which assemble into an oligomer called necrosome. Accumulating evidence reveals that necroptosis participates in many types of pathological processes. Hence, clarifying the mechanism of necroptosis in pathological processes is particularly important for the prevention and treatment of various diseases. For over 300 years, hydrogen sulfide (H₂S) has been widely known in the scientific community as a toxic and foul-smelling gas. However, after discovering the important physiological and pathological functions of H₂S, human understanding of this small molecule changed, believing that H₂S is the third gas signaling molecule after carbon monoxide (CO) and nitric oxide (NO). H₂S plays an important role in various diseases, but the related mechanisms are not yet fully understood. In recent years, more and more studies have shown that H₂S regulation of necroptosis is involved in various pathological processes. Herein, we focus on the recent progress on the role of H₂S regulation of necroptosis in different pathological processes and profoundly analyze the related mechanisms.