Association of biomarkers and Barthel Index with occurrence of age-related adverse health outcomes in individuals with diabetes

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-08-14 DOI:10.1111/jdi.14286

Kotaro Umamoto, Ryotaro Bouchi, Kotaro Soeda, Shosuke Satake, Tohru Hosoyama, Mitsuru Ohsugi, Kohjiro Ueki, Hiroshi Kajio

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Abstract

Aims/Introduction

The clinical significance of age-related biomarkers in patients with diabetes has not been fully elucidated. In this study, we aimed to establish models to predict the progression of aging in patients with diabetes using biomarkers.

Materials and Methods

This single-center, retrospective cohort study included 115 Japanese patients with diabetes aged ≥60 years. Age-related adverse health outcomes were defined as emergency hospitalization, any increase in the level of nursing care certification, admission to a nursing home or death. The associations of age-related biomarker levels (adiponectin, growth differentiation factor 15 [GDF15], C-X-C motif chemokine ligand 9 and apelin) and clinical indicators with age-related adverse health outcomes were evaluated. Factors that predominantly influenced the occurrence of age-related adverse health outcomes were explored using the Cox proportional hazards model.

Results

The mean age of the 115 participants was 73 years, 50.6% were men, the mean body mass index and hemoglobin A1c level were 25.3 kg/m² and 9.79%, respectively. There were 26 age-related adverse health outcomes during the study period (median 1.93, range 0–4.65 years). In a model combining clinical indicators and biomarkers, including the Barthel Index, GDF15 and adiponectin, the occurrence of age-related adverse health outcomes was found to be significantly associated with GDF15 and Barthel Index. The group with both GDF15 and adiponectin levels higher than the median proved to be significantly higher than the group with both lower.

Conclusions

The measurement of GDF15 and adiponectin levels and the Barthel Index might be useful for predicting age-related adverse health outcomes in patients with diabetes.

Abstract Image

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生物标志物和 Barthel 指数与糖尿病患者出现与年龄相关的不良健康后果的关系。

目的/引言：糖尿病患者年龄相关生物标志物的临床意义尚未完全阐明。在这项研究中，我们旨在利用生物标志物建立预测糖尿病患者衰老进程的模型：这项单中心回顾性队列研究纳入了 115 名年龄≥60 岁的日本糖尿病患者。与年龄相关的不良健康后果被定义为急诊住院、护理证明级别增加、入住疗养院或死亡。评估了与年龄相关的生物标志物水平（脂肪连素、生长分化因子 15 [GDF15]、C-X-C 矩阵趋化因子配体 9 和 apelin）和临床指标与与年龄相关的不良健康后果之间的关联。采用 Cox 比例危险模型探讨了主要影响年龄相关不良健康后果发生的因素：115 名参与者的平均年龄为 73 岁，50.6% 为男性，平均体重指数和血红蛋白 A1c 水平分别为 25.3 kg/m2 和 9.79%。在研究期间，共有 26 例与年龄相关的不良健康后果（中位数为 1.93，范围为 0-4.65 年）。在一个结合临床指标和生物标志物（包括巴特尔指数、GDF15和脂肪连素）的模型中，发现与年龄相关的不良健康后果的发生与GDF15和巴特尔指数显著相关。事实证明，GDF15和脂肪连蛋白水平均高于中位数的组别，其不良健康后果的发生率明显高于两者均低于中位数的组别：结论：测量 GDF15 和脂肪连接蛋白水平以及 Barthel 指数可能有助于预测糖尿病患者与年龄相关的不良健康后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).