Pharmacological management of heart failure in adults with congenital heart disease.

IF 4.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Heart Failure Reviews Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI:10.1007/s10741-024-10428-4
Barbara Karnkowska, Wissam Harmouch, Peter Newman, Hamza Malik, Bisma Khwaja, Alexandra Lewis, Mohammed Faluk, Khaled Chatila
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Abstract

Congenital heart disease (CHD) is the most common global congenital defect affecting over 2.4 million individuals in the United States. Ongoing medical and surgical advancements have improved the survival of children with CHD leading to a shift where, as of 2010, adults constitute two-thirds of the CHD patient population. The increasing number and aging of adult congenital heart disease (ACHD) patients present a clinical challenge due to heightened complexity, morbidity, and mortality. Studies indicate that 1 in 13 ACHD patients will develop heart failure (HF) in their lifetime. ACHD-HF patients experience more frequent emergency department visits, higher hospitalization rates, longer hospital stays, and higher mortality compared to non-ACHD patients with heart failure (non-ACHD-HF). Despite HF being the leading cause of death in ACHD patients, there is a notable gap in evidence regarding treatment. While guideline-directed medical therapy (GDMT) has been extensively studied in non-ACHD-HF, research specific to ACHD-HF individuals is limited. This article aims to comprehensively review available literature addressing the pharmacological treatment of ACHD-HF.

Abstract Image

先天性心脏病成人心力衰竭的药物治疗。
先天性心脏病(CHD)是全球最常见的先天性缺陷,在美国影响着 240 多万人。医疗和外科手术的不断进步提高了儿童先天性心脏病患者的存活率,截至 2010 年,成人先天性心脏病患者已占总人数的三分之二。成人先天性心脏病(ACHD)患者的数量和年龄都在不断增加,由于其复杂性、发病率和死亡率都有所提高,这给临床治疗带来了挑战。研究表明,每 13 名 ACHD 患者中就有一人会在一生中患上心力衰竭(HF)。与非 ACHD 心衰患者(非 ACHD-HF)相比,ACHD-HF 患者的急诊就诊频率更高,住院率更高,住院时间更长,死亡率更高。尽管心力衰竭是导致 ACHD 患者死亡的主要原因,但在治疗方面却存在明显的证据差距。虽然指南指导的医疗疗法(GDMT)已在非 ACHD-HF 患者中得到广泛研究,但针对 ACHD-HF 患者的研究却很有限。本文旨在全面回顾有关 ACHD-HF 药物治疗的现有文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Heart Failure Reviews
Heart Failure Reviews 医学-心血管系统
CiteScore
10.40
自引率
2.20%
发文量
90
审稿时长
6-12 weeks
期刊介绍: Heart Failure Reviews is an international journal which develops links between basic scientists and clinical investigators, creating a unique, interdisciplinary dialogue focused on heart failure, its pathogenesis and treatment. The journal accordingly publishes papers in both basic and clinical research fields. Topics covered include clinical and surgical approaches to therapy, basic pharmacology, biochemistry, molecular biology, pathology, and electrophysiology. The reviews are comprehensive, expanding the reader''s knowledge base and awareness of current research and new findings in this rapidly growing field of cardiovascular medicine. All reviews are thoroughly peer-reviewed before publication.
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