The Impact of COVID-19 Infection on Abdominal Aortic Aneurysms: Mechanisms and Clinical Implications

IF 3.4 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Zenghan Cao, Jianhang Gao, Jianqiang Wu, Yuehong Zheng
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引用次数: 0

Abstract

Background: The COVID-19 virus not only has significant pathogenicity but also influences the progression of many diseases, altering patient prognosis. Cardiovascular diseases, particularly aortic aneurysms, are among the most life-threatening conditions.

Main Idea: COVID-19 infection is reported to accelerate the progression of abdominal aortic aneurysms (AAAs) and increase the risk of rupture; however, a comprehensive understanding of the underlying mechanisms remains elusive. This article primarily reviews the relevant foundational research, focusing on disruptions in the renin-angiotensin-aldosterone system (RAAS), immune system activation, and coagulation disorders. Furthermore, we summarize related clinical research, including the epidemiology of aortic aneurysms during the pandemic and specific case studies.

Conclusion: COVID-19 infection can influence the onset and progression of aortic aneurysms by affecting the RAAS, triggering inflammation and immune dysregulation in the arterial wall, and inducing a hypercoagulation state. It is crucial to comprehensively understand the impact of pandemic viral infections on aortic diseases at the foundational and clinical levels, thereby identifying potential preventative or therapeutic approaches and preparing for potential future outbreaks.

Abstract Image

COVID-19 感染对腹主动脉瘤的影响:机制与临床意义
背景:COVID-19 病毒不仅具有显著的致病性,而且会影响许多疾病的进展,改变患者的预后。心血管疾病,尤其是主动脉瘤,是最危及生命的疾病之一:据报道,COVID-19 感染会加速腹主动脉瘤(AAA)的进展,并增加破裂的风险;然而,对其潜在机制的全面了解仍是空白。本文主要回顾了相关的基础研究,重点关注肾素-血管紧张素-醛固酮系统(RAAS)的紊乱、免疫系统激活和凝血功能障碍。此外,我们还总结了相关的临床研究,包括大流行期间主动脉瘤的流行病学和具体病例研究:结论:COVID-19 感染可通过影响 RAAS、引发动脉壁炎症和免疫失调以及诱发高凝状态来影响主动脉瘤的发生和发展。从基础和临床层面全面了解大流行性病毒感染对主动脉疾病的影响至关重要,从而确定潜在的预防或治疗方法,并为未来可能爆发的疫情做好准备。
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来源期刊
Cardiovascular Therapeutics
Cardiovascular Therapeutics 医学-心血管系统
CiteScore
5.60
自引率
0.00%
发文量
55
审稿时长
6 months
期刊介绍: Cardiovascular Therapeutics (formerly Cardiovascular Drug Reviews) is a peer-reviewed, Open Access journal that publishes original research and review articles focusing on cardiovascular and clinical pharmacology, as well as clinical trials of new cardiovascular therapies. Articles on translational research, pharmacogenomics and personalized medicine, device, gene and cell therapies, and pharmacoepidemiology are also encouraged. Subject areas include (but are by no means limited to): Acute coronary syndrome Arrhythmias Atherosclerosis Basic cardiac electrophysiology Cardiac catheterization Cardiac remodeling Coagulation and thrombosis Diabetic cardiovascular disease Heart failure (systolic HF, HFrEF, diastolic HF, HFpEF) Hyperlipidemia Hypertension Ischemic heart disease Vascular biology Ventricular assist devices Molecular cardio-biology Myocardial regeneration Lipoprotein metabolism Radial artery access Percutaneous coronary intervention Transcatheter aortic and mitral valve replacement.
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