Cardiopulmonary Exercise Testing-Guided Exercise Therapy in Hypertensive Patients: A Single Center Study

IF 3.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Therapeutics Pub Date : 2024-08-08 DOI:10.1155/2024/8476971

Qin Lu, Jingjing Lu, Che Li, Ping Huang, Fenfen Jiang, Xia Zhao, Jianqin Zhang, Yi Huang, Zhenliang Chu

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Abstract

Objective: To observe the effects of cardiac rehabilitation guided by cardiopulmonary exercise testing (CPET) on cardiorespiratory reserve function, blood pressure, blood pressure variability, and lipid metabolism in patients with hypertension.

Methods: A randomized trial enrolled 67 Grade 1 hypertensive patients on antihypertensive drugs, divided into conventional (n = 35) and CPET (n = 32) groups. Antihypertensive drugs were not adjusted in both groups during the study period. Blood pressure, cardiorespiratory indicators, lipid profile, and BMI were assessed pre/post 12 weeks.

Results: Postintervention, the CPET group exhibited significantly lower blood pressure levels and improved cardiac indicators compared to the conventional group (p < 0.05). CPET group showed greater improvements in cardiorespiratory endurance indicators (p < 0.05). The cardiorespiratory endurance indicators showed significantly greater increases in the CPET group compared to the conventional group (p < 0.05). Low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), and body mass index (BMI) were significantly lower in the CPET group (p < 0.05).

Conclusion: In addition to drug treatment, cardiac rehabilitation guided by CPET can effectively improve blood pressure control, reduce blood pressure variability, improve cardiorespiratory function and lipid metabolism, and increase exercise endurance in patients with Grade 1 hypertension. Its efficacy is clear and safe, with clinical value for promotion.

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高血压患者心肺运动测试指导下的运动疗法：单中心研究

目的观察心肺运动测试（CPET）指导下的心脏康复对高血压患者心肺储备功能、血压、血压变异性和脂质代谢的影响：一项随机试验招募了 67 名服用降压药的 1 级高血压患者，分为常规组（35 人）和 CPET 组（32 人）。两组患者在研究期间均未调整降压药物。在 12 周前/后对血压、心肺功能指标、血脂和体重指数进行评估：干预后，与常规组相比，CPET 组的血压水平明显降低，心脏指标明显改善（p < 0.05）。CPET 组的心肺耐力指标有较大改善（p < 0.05）。与常规组相比，CPET 组的心肺耐力指标明显增加（p < 0.05）。CPET组的低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、甘油三酯（TG）和体重指数（BMI）明显降低（p < 0.05）：除药物治疗外，CPET 指导下的心脏康复治疗可有效改善 1 级高血压患者的血压控制，降低血压变异性，改善心肺功能和脂质代谢，提高运动耐力。其疗效明确、安全性高，具有临床推广价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Therapeutics 医学-心血管系统

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Cardiovascular Therapeutics (formerly Cardiovascular Drug Reviews) is a peer-reviewed, Open Access journal that publishes original research and review articles focusing on cardiovascular and clinical pharmacology, as well as clinical trials of new cardiovascular therapies. Articles on translational research, pharmacogenomics and personalized medicine, device, gene and cell therapies, and pharmacoepidemiology are also encouraged. Subject areas include (but are by no means limited to): Acute coronary syndrome Arrhythmias Atherosclerosis Basic cardiac electrophysiology Cardiac catheterization Cardiac remodeling Coagulation and thrombosis Diabetic cardiovascular disease Heart failure (systolic HF, HFrEF, diastolic HF, HFpEF) Hyperlipidemia Hypertension Ischemic heart disease Vascular biology Ventricular assist devices Molecular cardio-biology Myocardial regeneration Lipoprotein metabolism Radial artery access Percutaneous coronary intervention Transcatheter aortic and mitral valve replacement.

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