Anticandidal Properties of Launaea sarmentosa among the Salt Marsh Plants Collected from Palk Bay and the Gulf of Mannar Coast, Southeastern India

Antibiotics Pub Date : 2024-08-09 DOI:10.3390/antibiotics13080748

Smriti Das, Karuppannagounder Rajan Priyanka, Kolandhasamy Prabhu, Ramachandran Vinayagam, Rajendran Rajaram, Sang Gu Kang

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Abstract

Tidal wetlands, commonly known as salt marshes, are highly productive ecosystems in temperate regions worldwide. These environments constitute a unique flora composed primarily of salt-tolerant herbs, grasses, and shrubs. This study investigated the therapeutic properties of ten salt marsh plants collected mainly from Palk Bay and Mannar Gulf against Candida disease. This study examined the changes in natural plant products associated with their anti-Candida growth activity during two distinct seasonal changes—monsoon and summer. The potential of the salt marshes to inhibit the growth of five different Candida strains was assessed using four solvents. In phytochemical analysis, the extracts obtained from a Launaea sarmentosa exhibited the highest results compared to the other plant extracts. Fourier transform infrared spectroscopy revealed 12 peaks with alkane, aldehyde, amine, aromatic ester, phenol, secondary alcohol, and 1,2,3,4-tetrasubstituted. Gas-chromatography–mass spectrometry detected 30 compounds. Cyclotetracosane, lupeol, β-amyrin, and 12-oleanen-3-yl acetate showed the highest peak range. In particular, plant samples collected during the monsoon season were more effective in preventing Canda growth than the summer plant samples. In the monsoon season, the salt marsh plant extracted with ethyl acetate showed a high anti-Candida growth activity, while in the summer, the acetone extract exhibited a higher anti-Candida growth activity than the other solvents. The hexane extract of L. sarmentosa showed the highest inhibition zone against all Candidal strains. Furthermore, compounds, such as β-amyrin, lupeol, and oxirane, from the hexane extract of L. sarmentosa play a vital role in anti-Candida activity. This paper reports the potential of tidal marsh plant extracts for developing new antifungal agents for Candida infections.

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从印度东南部帕克湾和马纳尔湾沿岸采集的盐沼植物中的 Launaea sarmentosa 的杀菌特性

潮汐湿地通常被称为盐沼，是全球温带地区高产的生态系统。这些环境构成了独特的植物区系，主要由耐盐性草本植物、草和灌木组成。本研究调查了主要从帕克湾和马纳尔湾采集的十种盐沼植物对念珠菌病的治疗特性。这项研究考察了天然植物产品在两个不同季节--季风季节和夏季--中与抗念珠菌生长活性相关的变化。使用四种溶剂对盐沼抑制五种不同念珠菌菌株生长的潜力进行了评估。在植物化学分析中，与其他植物提取物相比，从 Launaea sarmentosa 提取物中获得的结果最高。傅立叶变换红外光谱显示出 12 个峰值，包括烷、醛、胺、芳香酯、酚、仲醇和 1，2，3，4-四取代。气相色谱-质谱法检测出 30 种化合物。环十四烷、羽扇豆醇、β-amyrin 和 12-oleanen-3-yl acetate 的峰值范围最大。尤其是季风季节采集的植物样本比夏季采集的植物样本更能有效地阻止康达的生长。在季风季节，用乙酸乙酯提取的盐沼植物显示出较高的抗念珠菌生长活性，而在夏季，丙酮提取物显示出比其他溶剂更高的抗念珠菌生长活性。沙门氏菌的正己烷提取物对所有念珠菌菌株的抑制面积最大。此外，潮霉素己烷提取物中的β-amyrin、lupeol 和 oxirane 等化合物在抗念珠菌活性中发挥了重要作用。本文报告了潮汐沼泽植物提取物在开发治疗念珠菌感染的新型抗真菌药物方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antibiotics

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