{"title":"Neurons Structure and Cytokine Expression after Lithium Carbonate Treatment on Melanoma Mice Model","authors":"N. A. Obanina, N. P. Bgatova, I. D. Ivanov","doi":"10.1134/s1990519x2470041x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Tumor-produced pro-inflammatory cytokines and toxic substances passing through the blood-brain barrier can cause disturbances of brain homeostasis and neuronal damage. Correction of brain homeostasis under peripheral tumor growth conditions is an important task. In the present study, a cytokine expression in the brain and ultrastructural features of the prefrontal cortex pyramidal neurons in animals with skin melanoma and after lithium carbonate treatment were detected by PCR analysis, transmission electron microscopy, and immunohistochemical staining. The low expression levels of the neurotrophic factor BDNF and an increase expression of colony-stimulating factors G-CSF and GM-CSF were noted in animals with skin melanoma. At the same time, as welling of mitochondria, inner mitochondrial membrane damage and dilated endoplasmic reticulum were revealed in the prefrontal cortex neurons. Furthermore, the predominance of autophagosomes was revealed under peripheral tumor growth conditions. Lithium carbonate administration had a corrective effect on the cytokine expression in the brain and the ultrastructure of the prefrontal cortex neurons in animals with skin melanoma.</p>","PeriodicalId":9705,"journal":{"name":"Cell and Tissue Biology","volume":"44 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Tissue Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s1990519x2470041x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
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Abstract
Tumor-produced pro-inflammatory cytokines and toxic substances passing through the blood-brain barrier can cause disturbances of brain homeostasis and neuronal damage. Correction of brain homeostasis under peripheral tumor growth conditions is an important task. In the present study, a cytokine expression in the brain and ultrastructural features of the prefrontal cortex pyramidal neurons in animals with skin melanoma and after lithium carbonate treatment were detected by PCR analysis, transmission electron microscopy, and immunohistochemical staining. The low expression levels of the neurotrophic factor BDNF and an increase expression of colony-stimulating factors G-CSF and GM-CSF were noted in animals with skin melanoma. At the same time, as welling of mitochondria, inner mitochondrial membrane damage and dilated endoplasmic reticulum were revealed in the prefrontal cortex neurons. Furthermore, the predominance of autophagosomes was revealed under peripheral tumor growth conditions. Lithium carbonate administration had a corrective effect on the cytokine expression in the brain and the ultrastructure of the prefrontal cortex neurons in animals with skin melanoma.
期刊介绍：
The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.
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