Biosynthesis of Ag/Cu nanocomposite mediated by Curcuma longa: Evaluation of its antibacterial properties against oral pathogens

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Open Chemistry Pub Date : 2024-08-06 DOI:10.1515/chem-2024-0059

Huanfang Yan, Li Wang, Yanfei Mu

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Abstract

Curcuma longa is a popular plant around the world with various applications in food and medicinal aspects. An investigation has been conducted on the formulation of Ag/Cu nanocomposite by C. longa as a natural stabilizing agent, without the use of any toxic or harmful reagents. This bio-inspired approach is focused on applicative, facile, and green chemical research. The study also explored the potential of Ag/Cu nanocomposite to prevent dental bacteria growth and prevent adherence in vitro. The biomediated Ag/Cu@ turmeric NCs were characterized by advanced physicochemical techniques. The FE-SEM imaging has established that Ag/Cu@ turmeric has a semi-spherical shape (60.92 nm). The crystallinity of nanocomposite has been confirmed by the XRD technique. Subsequently, the biological activity of the Ag/Cu nanocomposite functionalized with biomolecules was examined. The concentration of 1,000 µg/mL showed the most effective minimum inhibitory concentrations (MICs) against Porphyromonas gingivalis and Streptococcus mutans (MIC = 16 µg/mL) during the investigation. The addition of Ag/Cu nanocomposite (MIC = 32 µg/mL) significantly hindered the S. mutans in vitro adherence. According to the findings of this research, Ag/Cu nanocomposite could potentially serve as an effective oral hygiene agent for managing periodontopathic and dental caries conditions.

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莪术介导的银/铜纳米复合材料的生物合成：评估其对口腔病原体的抗菌特性

莪术是世界上一种广受欢迎的植物，在食品和医药方面有多种用途。研究人员利用莪术作为天然稳定剂，在不使用任何有毒或有害试剂的情况下，配制出银/铜纳米复合材料。这种受生物启发的方法侧重于应用性、简便性和绿色化学研究。该研究还探索了银/铜纳米复合材料在体外防止牙科细菌生长和粘附的潜力。研究人员采用先进的理化技术对生物介导的银/铜@姜黄纳米复合材料进行了表征。FE-SEM成像结果表明，Ag/Cu@姜黄具有半球形形状（60.92 nm）。XRD 技术证实了纳米复合材料的结晶性。随后，研究人员考察了具有生物大分子功能的 Ag/Cu 纳米复合材料的生物活性。在研究过程中，1,000 µg/mL 的浓度显示出对牙龈卟啉单胞菌和变异链球菌（MIC = 16 µg/mL）最有效的最小抑菌浓度（MIC）。添加了银/铜纳米复合材料（MIC = 32 µg/mL）后，可显著抑制变异链球菌的体外粘附。根据这项研究的结果，Ag/Cu 纳米复合材料有可能成为一种有效的口腔卫生剂，用于治疗牙周病和龋齿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

6 weeks

期刊介绍： Open Chemistry is a peer-reviewed, open access journal that publishes original research, reviews and short communications in the fields of chemistry in an ongoing way. The central goal is to provide a hub for researchers working across all subjects to present their discoveries, and to be a forum for the discussion of the important issues in the field. The journal is the premier source for cutting edge research in fundamental chemistry and it provides high quality peer review services for its authors across the world. Moreover, it allows for libraries everywhere to avoid subscribing to multiple local publications, and to receive instead all the necessary chemistry research from a single source available to the entire scientific community.