Europium-based complex crosslinked with hyaluronic acid sponge with controllable adaptive capability to promote effective scarless regeneration of burn wound

IF 7.2 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Applied Materials Today Pub Date : 2024-07-21 DOI:10.1016/j.apmt.2024.102340

Xiuhong Huang, Liqin Zheng, Lihua Li, Licheng Lin, Zonghua Liu, Changren Zhou

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引用次数: 0

Abstract

The occurrence of severe skin burns may lead to delayed wound healing and persistent scarring. Agents that promote angiogenesis hold great promise for enhancing the effectiveness of wound healing, while modulation of oxidative stress, inflammation, and anti-fibrotic cytokines exhibits significant potential in alleviating scars. In this study, a novel hyaluronic acid- chitooligosaccharides/europium (HA-CE) sponge was prepared. HA-CE sponge were highly absorbent and could scavenge free radicals, as well as promoted macrophages polarized toward M2. HA-CE sponge also promoted the angiogenesis, which was related to the increased vascular endothelial growth factor (VEGF) expression. The expression of CD26 in fibroblast was down-regulated and the transforming growth factor-β3 (TGF-β3) was elevated by HA-CE sponge. The HA-CE sponge in the burnt wound model enhanced angiogenesis and anti-inflammatory responses, thereby accelerating healing of burnt wounds and ameliorating scarring-related factors to inhibit scar formation. These findings identified HA-CE sponge had potential to be developed as a dressing for burnt skin wound.

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与透明质酸海绵交联的铕基复合物具有可控的适应能力，可促进烧伤创面的有效无痕再生

严重皮肤烧伤可能导致伤口延迟愈合和疤痕持续存在。促进血管生成的药物在提高伤口愈合效果方面大有可为，而调节氧化应激、炎症和抗纤维化细胞因子则在减轻疤痕方面表现出巨大潜力。本研究制备了一种新型透明质酸-壳寡糖/铕（HA-CE）海绵。透明质酸-壳寡糖/铕（HA-CE）海绵具有高吸收性，能清除自由基，促进巨噬细胞向M2极化。HA-CE 海绵还能促进血管生成，这与血管内皮生长因子（VEGF）表达的增加有关。HA-CE 海绵可下调成纤维细胞中 CD26 的表达，并升高转化生长因子-β3（TGF-β3）。烧伤模型中的 HA-CE 海绵增强了血管生成和抗炎反应，从而加速了烧伤伤口的愈合，并改善了疤痕相关因素，抑制了疤痕的形成。这些研究结果表明，HA-CE 海绵具有开发为烧伤皮肤伤口敷料的潜力。

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来源期刊

Applied Materials Today Materials Science-General Materials Science

CiteScore

14.90

自引率

3.60%

发文量

393

审稿时长

26 days

期刊介绍： Journal Name: Applied Materials Today Focus: Multi-disciplinary, rapid-publication journal Focused on cutting-edge applications of novel materials Overview: New materials discoveries have led to exciting fundamental breakthroughs. Materials research is now moving towards the translation of these scientific properties and principles.