Design and fabrication of smart functional hydrogel wound dressing for diabetic foot ulcer

IF 2.5 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Frontiers of Materials Science Pub Date : 2024-08-08 DOI:10.1007/s11706-024-0691-y

Yufei Wang, Dandan Hou, Hui Zhao, Xue Geng, Xin Wu, Gaobiao Li, Fei Sha, Zengguo Feng, Zongjian Liu, Lin Ye

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引用次数: 0

Abstract

Diabetic foot ulcer (DFU) often evolves into chronic wounds that resist healing over an extended period, sometimes necessitating amputation in severe cases. Traditional wound management approaches generally fail to control these chronic sores successfully. Thus, it arouses a huge demand in clinic for a novel wound dressing to treat DFU effectively. Hydrogel as an ideal delivery system exhibits excellent loading capacity and sustainable release behavior. It also boasts tunable physical and chemical properties adaptable to diverse biomedical scenarios, making it a suitable material for fabricating functional wound dressings to treat DFU. The hydrogel dressings are classified into hemostatic, antibacterial and anti-inflammatory, and healing-promoting hydrogel dressings by associating the pathogenesis of DFU in this paper. The design and fabrication strategies for the dressings, as well as their therapeutic effects in treating DFU, are extensively reviewed. Additionally, this paper highlights future perspectives of multifunctional hydrogel dressings in DFU treatment. This review aims to provide valuable references for material scientists to design and develop hydrogel wound dressings with enhanced capabilities for DFU treatment, and to further translate them into the clinic in the future.

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设计和制造用于糖尿病足溃疡的智能功能性水凝胶伤口敷料

糖尿病足溃疡（DFU）经常演变成慢性伤口，长期难以愈合，严重者有时需要截肢。传统的伤口处理方法通常无法成功控制这些慢性溃疡。因此，临床上迫切需要一种新型伤口敷料来有效治疗 DFU。水凝胶作为一种理想的给药系统，具有出色的负载能力和可持续释放特性。水凝胶还具有可调的物理和化学特性，能适应各种生物医学情况，因此是制造治疗 DFU 的功能性伤口敷料的合适材料。本文结合 DFU 的发病机理，将水凝胶敷料分为止血型、抗菌消炎型和促进愈合型水凝胶敷料。本文广泛综述了敷料的设计和制造策略，以及它们在治疗 DFU 方面的疗效。此外，本文还强调了多功能水凝胶敷料在 DFU 治疗中的未来前景。本综述旨在为材料科学家提供有价值的参考，帮助他们设计和开发具有更强功能的水凝胶伤口敷料，用于治疗 DFU，并在未来进一步将其应用于临床。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers of Materials Science MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

4.20

自引率

3.70%

发文量

515

期刊介绍： Frontiers of Materials Science is a peer-reviewed international journal that publishes high quality reviews/mini-reviews, full-length research papers, and short Communications recording the latest pioneering studies on all aspects of materials science. It aims at providing a forum to promote communication and exchange between scientists in the worldwide materials science community. The subjects are seen from international and interdisciplinary perspectives covering areas including (but not limited to): Biomaterials including biomimetics and biomineralization; Nano materials; Polymers and composites; New metallic materials; Advanced ceramics; Materials modeling and computation; Frontier materials synthesis and characterization; Novel methods for materials manufacturing; Materials performance; Materials applications in energy, information and biotechnology.