Neutrophil-Lymphocyte Ratio: Adjunct Prognostic Biomarker in Oral Squamous Cell Carcinoma (OSCC) – A Study in Delhi NCR

International Journal of Health Sciences and Research Pub Date : 2024-08-08 DOI:10.52403/ijhsr.20240824

Mihir Sharma, C. Agarwal, M. Pujani

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Abstract

Background: Inflammation is now recognized as the seventh hallmark of cancer. Neutrophil-lymphocyte ratio holds promise as an adjunct biomarker in various cancers. Materials and methods: 32 biopsy-confirmed OSCC patients and 32 healthy controls were enrolled in this prospective case-control study and venous blood samples were obtained and CBC reports were thus used for analysis of various haematological parameters such as NLR, using t-test, and Mann-Whitney U test using STATA. Results: The median NLR was found to be raised in OSCC patients as compared to healthy controls and the difference was found to be statistically significant ((Median:3.83(2.31-5.56) vs. 2.14(1.80-2.66), p=0.0006) Conclusions : NLR can be used as a useful tool for clinicians as an adjunct biomarker for the prognostication and potentially help in the diagnosis of OSCC in screening. Future studies should include a larger sample size and should be longitudinal in nature as well as should explore differences in NLR in benign, premalignant and malignant cases. Key words: Neutrophil-lymphocyte ratio, biomarker, oral squamous cell carcinoma, cancer, hematological

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中性粒细胞-淋巴细胞比率：口腔鳞状细胞癌 (OSCC) 的辅助预后生物标志物--德里 NCR 地区的一项研究

背景：炎症现已被认为是癌症的第七大标志。材料与方法：这项前瞻性病例对照研究招募了 32 名经活检确诊的 OSCC 患者和 32 名健康对照者，并采集了静脉血样本和 CBC 报告，使用 t 检验和 STATA 的 Mann-Whitney U 检验分析 NLR 等各种血液学参数。结果：与健康对照组相比，OSCC 患者的 NLR 中位数升高，差异具有统计学意义（中位数：3.83(2.31-5.56) vs. 2.14(1.80-2.66), p=0.0006）：NLR可作为临床医生预后的辅助生物标志物，并有可能帮助筛查诊断OSCC。未来的研究应包括更大的样本量、纵向研究以及探讨良性、恶性前和恶性病例中 NLR 的差异：中性粒细胞-淋巴细胞比值生物标志物口腔鳞状细胞癌癌症血液学

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International Journal of Health Sciences and Research

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