Filling the gap: brief neuropsychological assessment protocol for glioma patients undergoing awake surgeries

Juliana Bastos Ohy, C. Formentin, Daniel Andrade Gripp, Joab Alves Nicácio Jr, M. Velho, Larissa Núbia Vilany, Gabriel Frizon Greggianin, Beatriz Sartori, Ana Carolina Pinheiro Campos, Silvia Mazzali Verst, Marcos Vinícius Calfat Maldaun
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Abstract

The literature lacks a concise neurocognitive test for assessing primary cognitive domains in neuro-oncological patients. This study aims to describe and assess the feasibility of the Ohy-Maldaun Fast Track Cognitive Test (OMFTCT), used to pre- and post-operatively evaluate patients undergoing brain tumor surgery in language eloquent areas. The cognitive diagnosis was used to safely guide intraoperative language assessment.This is a prospective longitudinal observational clinical study conducted on a cohort of 50 glioma patients eligible for awake craniotomies. The proposed protocol assesses multiple cognitive domains, including language, short-term verbal and visual memories, working memory, praxis, executive functions, and calculation ability. The protocol comprises 10 different subtests, with a maximum score of 50 points, and was applied at three time points: preoperative, immediately postoperative period, and 30 days after surgery.Among the initial 50 patients enrolled, 36 underwent assessment at all three designated time points. The mean age of the patients was 45.3 years, and they presented an average of 15 years of education. The predominant tumor types included Glioblastoma, IDH-wt (44.1%), and diffuse astrocytoma, IDH-mutant (41.2%). The tumors were located in the left temporal lobe (27.8%), followed by the left frontal lobe (25%). The full test had an average application time of 23 min.OMFTCT provided pre- and postoperative assessments of different cognitive domains, enabling more accurate planning of intraoperative language testing. Additionally, recognition of post-operative cognitive impairments played a crucial role in optimizing patient care.
填补空白:为接受清醒手术的胶质瘤患者提供简短的神经心理学评估方案
文献中缺乏用于评估神经肿瘤患者主要认知领域的简明神经认知测试。本研究旨在描述和评估Ohy-Maldaun快速认知测试(OMFTCT)的可行性,该测试用于在语言能力强的地区对接受脑肿瘤手术的患者进行术前和术后评估。认知诊断用于安全指导术中语言评估。这是一项前瞻性纵向观察临床研究,对象是符合清醒开颅手术条件的 50 名胶质瘤患者。拟议方案评估多个认知领域,包括语言、短期言语和视觉记忆、工作记忆、练习、执行功能和计算能力。该方案由 10 个不同的子测试组成,最高分为 50 分,在三个时间点进行评估:术前、术后即刻和术后 30 天。患者的平均年龄为 45.3 岁,平均受教育年限为 15 年。主要肿瘤类型包括胶质母细胞瘤,IDH-wt(44.1%)和弥漫性星形细胞瘤,IDH-mutant(41.2%)。肿瘤位于左侧颞叶(27.8%),其次是左侧额叶(25%)。整个测试的平均应用时间为23分钟。OMFTCT提供了不同认知领域的术前和术后评估,使术中语言测试的规划更加准确。此外,识别术后认知障碍对优化患者护理也起到了至关重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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