Inflammatory Response and Pathophysiology of IL-6 Overproduction: A Review Article

Abstract

Interleukin-6 (IL-6) has been considered a multifunctional interleukin, belongs to the pro-inflammatory cytokines, stimulate the production of various polypeptides accounted for acute inflammatory response, and exerts a crucial function in the cells’ division, survival and differentiation of and is responsible for many cellular metabolic alterations. Interleukin (IL)-6 is formed at the location of inflammatory response and perform a principal function in the acute inflammatory phase stage by the release of many acute phase polypeptides. Overproduction of IL-6 has been found to be a major cause in the pathophysiology of several illnesses including post-menopausal osteoporosis, psoriasis, Castleman’s disease, rheumatoid arthritis, inflammatory bowel disease, pyelonephritis and multiple myeloma. Studies suggested that IL-6 can be recommended as a key indicator for prediction of elongated COVID-19 status and to determine “early stage” of extended COVID-19. This review aims to state the main mechanisms by which Il-6 exert its role during inflammatory response and its pathophysiological aspects in the development of many diseases