An Unusual Overlap of Lipoid Proteinosis and Cutaneous Amyloidosis – A Case Report

Abstract

Lipoid proteinosis is a rare genodermatosis that primarily affects the skin and mucous membranes of the respiratory and digestive systems. Cutaneous amyloidosis is characterised by deposition of amyloid protein in the upper papillary dermis. The present case is a 32-year-old male who presented with asymptomatic multiple raised skin coloured lesions and hoarseness of voice since childhood. On examination, he had multiple skin coloured and yellow waxy papules, some discrete and others coalescing to form plaques over the trunk, neck, upper and lower limbs. He also had multiple hyperpigmented papules and plaques on the back and neck, and ovoid shaped scars on the back. Examination of the eyelids revealed moniliform blepharosis, and there were pock like scars on the face. Indentations were present on the lateral and anterior borders of the tongue. Biopsy confirmed the same with few areas positive for Congo red staining. Overlap of lipoid proteinosis and macular amyloidosis was diagnosed. We report this overlap condition for its rarity.