Role of exosomal non‑coding RNAs in ovarian cancer (Review).

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of molecular medicine Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI:10.3892/ijmm.2024.5411
Xinchen Wang, Miao Yang, Jiamei Zhu, Yu Zhou, Gencui Li
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引用次数: 0

Abstract

Ovarian cancer (OC) is a common gynecological disease with a high mortality rate worldwide due to its insidious nature and undetectability at an early stage. The standard treatment, combining platinum‑based chemotherapy with cytoreductive surgery, has suboptimal results. Therefore, early diagnosis of OC is crucial. All cell types secrete extracellular vesicles, particularly exosomes. Exosomes, which contain lipids, proteins, DNA and non‑coding RNAs (ncRNAs), are novel methods of intercellular communication that participate in tumor development and progression. ncRNAs are categorized by size into long ncRNAs (lncRNAs) and small ncRNAs (sncRNAs). sncRNAs further include transfer RNAs, small nucleolar RNAs, PIWI‑interacting RNAs and microRNAs (miRNAs). miRNAs inhibit protein translation and promote messenger RNA (mRNA) cleavage to suppress gene expression. By sponging downstream miRNAs, lncRNAs and circular RNAs can regulate target gene expression, thereby weakening the interactions between miRNAs and mRNAs. Exosomes and exosomal ncRNAs, commonly present in human biological fluids, are promising biomarkers for OC. The present article aimed to review the potential role of exosomal ncRNAs in the diagnosis and prognosis of OC by summarizing the characteristics, processes, roles and isolation methods of exosomes and exosomal ncRNAs.

外泌体非编码 RNA 在卵巢癌中的作用(综述)。
卵巢癌(OC)是一种常见的妇科疾病,由于其隐匿性和早期不易被发现的特点,在全球范围内死亡率都很高。铂类化疗与细胞切除手术相结合的标准治疗效果并不理想。因此,OC 的早期诊断至关重要。所有类型的细胞都会分泌细胞外囊泡,尤其是外泌体。外泌体含有脂质、蛋白质、DNA和非编码RNA(ncRNA),是细胞间通信的新方法,参与肿瘤的发生和发展。ncRNA按大小分为长ncRNA(lncRNA)和小ncRNA(sncRNA)。sncRNA 还包括转运 RNA、小核仁 RNA、PIWI 相互作用 RNA 和 microRNA(miRNA)。miRNA 可抑制蛋白质翻译并促进信使 RNA(mRNA)裂解,从而抑制基因表达。lncRNAs 和环状 RNAs 可通过疏导下游 miRNAs 调节目标基因的表达,从而削弱 miRNAs 和 mRNAs 之间的相互作用。外泌体和外泌体 ncRNAs 通常存在于人体生物液体中,是很有前景的 OC 生物标记物。本文旨在通过总结外泌体和外泌体ncRNA的特点、过程、作用和分离方法,综述外泌体ncRNA在OC诊断和预后中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International journal of molecular medicine
International journal of molecular medicine 医学-医学:研究与实验
CiteScore
12.30
自引率
0.00%
发文量
124
审稿时长
3 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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