RNA ac4C modification in cancer: Unraveling multifaceted roles and promising therapeutic horizons

IF 9.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2024-08-14 DOI:10.1016/j.canlet.2024.217159

Wenhao Ouyang , Zhenjun Huang , Keyu Wan , Tiantian Nie , Haizhu Chen , Herui Yao

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Abstract

RNA modifications play a crucial role in cancer development, profoundly influencing various stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export, splicing, and translation in the cytoplasm. Among RNA modifications, RNA ac⁴C modification, also known as N4-acetylcytidine, stands out for its unique role in acetylation processes. Specific proteins regulate RNA ac⁴C modification, maintaining the dynamic and reversible nature of these changes. This review explores the molecular mechanisms and biological functions of RNA ac⁴C modification. It examines the intricate ways in which RNA ac⁴C modification influences the pathogenesis and progression of cancer. Additionally, the review provides an integrated overview of the current methodologies for detecting RNA ac⁴C modification. Exploring the potential applications of manipulating this modification suggests avenues for novel therapeutic strategies, potentially leading to more effective cancer treatments in the future.

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癌症中的 ac4C RNA 修饰：癌症中的 ac4C RNA 修饰：揭示多方面的作用和有希望的治疗前景。

RNA 的修饰在癌症的发展过程中起着至关重要的作用，对 RNA 生命周期的各个阶段产生深远影响。这些阶段包括核处理、核输出、剪接和在细胞质中的翻译。在 RNA 修饰中，ac4C RNA 修饰（又称 N4-乙酰胞苷）因其在乙酰化过程中的独特作用而脱颖而出。特定的蛋白质调控 ac4C RNA 修饰，保持了这些变化的动态性和可逆性。这篇综述探讨了 ac4C RNA 修饰的分子机制和生物功能。它探讨了 ac4C RNA 修饰影响癌症发病和进展的复杂方式。此外，该综述还综合概述了目前检测 ac4C RNA 修饰的方法。探索操纵这种修饰的潜在应用为新型治疗策略提供了途径，有可能在未来开发出更有效的癌症治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.