Prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes: A systematic review and meta-analysis

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-08-12 DOI:10.1111/jdi.14285

Kansak Boonpattharatthiti, Pirune Na Songkla, Junpen Chantara, Chanchanok Koomsri, Ines Krass, Nathorn Chaiyakunapruk, Teerapon Dhippayom

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Abstract

Introduction

The treatment of type 2 diabetes requires multidimensional management, with medication adherence a crucial aspect of diabetes control. However, recent rigorous estimates of adherence to oral antidiabetic drugs (OAD) are lacking. The objective of this study is to determine the prevalence of adherence to OAD in type 2 diabetes patients.

Methods

A systematic search was performed in PubMed, EMBASE, PsycINFO, and CINAHL from July 2013 to April 2023. Cross-sectional studies published in English were included if they met the following criteria: (1) reported the adherence to OAD using a validated measure; and (2) had a sample size of at least 385 patients with type 2 diabetes. The Joanna Briggs Institute critical appraisal for studies reporting prevalence data was used to assess the quality of the included studies. Pooled estimates of the prevalence of adherence to OAD were calculated as a percentage together with 95% confidence interval (95% CI) using a random-effect model. All analyses were conducted using STATA 17.0; PROSPERO (CRD42023414264).

Results

Twenty-six studies involving a total of 69,366 patients met the selection criteria and were included in the meta-analysis. The overall estimated prevalence of adherence to OAD was 55.53% (95%CI: 44.22%–66.85%). Among the included studies, nine were deemed to be of high quality. A sensitivity analysis conducted using only the high-quality studies revealed a prevalence of adherence to OAD at 52.24% (95% CI: 39.63%–64.85%).

Conclusions

The overall prevalence of adherence to OAD was remarkably low among type 2 diabetes patients worldwide. Healthcare practitioners and policy makers should employ appropriate approaches to improve adherence to OAD.

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2 型糖尿病患者坚持口服抗糖尿病药物的普遍性：系统回顾和荟萃分析。

导言：2 型糖尿病的治疗需要多方面的管理，其中坚持用药是糖尿病控制的一个重要方面。然而，近期缺乏对口服抗糖尿病药物（OAD）依从性的严格估计。本研究旨在确定 2 型糖尿病患者坚持服用 OAD 的普遍程度：方法：在 2013 年 7 月至 2023 年 4 月期间，对 PubMed、EMBASE、PsycINFO 和 CINAHL 进行了系统检索。符合以下标准的英文横断面研究均被纳入：(1) 使用经过验证的测量方法报告了 OAD 的依从性；(2) 样本量至少为 385 例 2 型糖尿病患者。乔安娜-布里格斯研究所（Joanna Briggs Institute）对报告患病率数据的研究进行了严格评估，以评估纳入研究的质量。采用随机效应模型，以百分比和95%置信区间（95% CI）的形式计算了OAD依从率的汇总估计值。所有分析均使用 STATA 17.0; PROSPERO (CRD42023414264) 进行：共有 26 项研究（涉及 69,366 名患者）符合筛选标准，并被纳入荟萃分析。据估计，坚持服用 OAD 的总体患病率为 55.53%（95%CI：44.22%-66.85%）。在纳入的研究中，有九项被认为是高质量研究。仅使用高质量研究进行的敏感性分析显示，坚持服用 OAD 的比例为 52.24%（95%CI：39.63%-64.85%）：结论：全球2型糖尿病患者坚持服用OAD的总体患病率非常低。医护人员和政策制定者应采用适当的方法来提高OAD的依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).