Acute urticaria and cardiovascular diseases

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI:10.1016/j.amjms.2024.08.004

Eli Magen MD , Eugene Merzon MD , Ilan Green MD , Israel Magen MD , Avivit Golan-Cohen MD , Shlomo Vinker MD , Ariel Israel MD, PhD

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引用次数: 0

Abstract

Background

Acute urticaria (AU), characterized by sudden skin wheals, has been associated with various triggers. While chronic urticaria's cardiovascular comorbidities have been studied, AU's associations remain largely unexplored.

Objective

This study aimed to identify prevalent cardiovascular comorbidities in AU patients and assess their clinical significance.

Methods

A retrospective cohort study used data from Leumit Health Services, matching AU patients with controls. Demographic, clinical, and laboratory data were analyzed. Statistical analyses included Fisher's Exact Test and Mann-Whitney U test.

Results

The AU group (72,851 individuals) showed no sex/ethnic distribution differences from controls (291,404 individuals). Systolic blood pressure, weight, BMI, glucose, hemoglobin A1c, C-reactive protein, eosinophil counts, total IgE levels were higher in AU (p < 0.001). Several cardiovascular comorbidities showed significant associations with AU, including valvular heart diseases (aortic regurgitation, mitral regurgitation, and pulmonary valve stenosis), cardiac arrhythmias (atrial fibrillation and others), deep vein thrombosis, diseases of capillaries, peripheral artery disease, cerebrovascular disease, coronary artery disease, and inflammatory heart diseases (pericarditis, heart failure, and hypertension) (p < 0.05). Medications, including antihistamines and glucocorticoids, were more prevalent in the AU group (p < 0.001).

Conclusion

This study's findings underscore the importance of recognizing cardiovascular comorbidities in AU patients and considering their implications for management. The observed associations provide insight into potential shared mechanisms between AU and cardiovascular diseases, though further research is needed to validate and expand upon these findings.

查看原文本刊更多论文

急性荨麻疹和心血管疾病。

背景：急性荨麻疹（AU）以突发性皮肤喘息为特征，与各种诱发因素有关。虽然慢性荨麻疹的心血管并发症已得到研究，但急性荨麻疹的相关性在很大程度上仍未得到探讨：本研究旨在确定荨麻疹患者普遍存在的心血管并发症，并评估其临床意义：一项回顾性队列研究使用了 Leumit 健康服务机构的数据，将 AU 患者与对照组进行配对。研究分析了人口统计学、临床和实验室数据。统计分析包括费雪精确检验和曼-惠特尼U检验：AU组（72851人）与对照组（291404人）在性别/种族分布上没有差异。非盟患者的收缩压、体重、体重指数、血糖、血红蛋白 A1c、C 反应蛋白、嗜酸性粒细胞计数和总 IgE 水平均较高（P < 0.001）。一些心血管合并症与 AU 有显著相关性，包括瓣膜性心脏病（主动脉瓣反流、二尖瓣反流和肺动脉瓣狭窄）、心律失常（心房颤动等）、深静脉血栓、毛细血管疾病、外周动脉疾病、脑血管疾病、冠状动脉疾病和炎症性心脏病（心包炎、心力衰竭和高血压）（P < 0.05）。包括抗组胺药和糖皮质激素在内的药物在非盟组中更为普遍（P < 0.001）：本研究的结果强调了认识到AU患者合并心血管疾病并考虑其对管理的影响的重要性。观察到的关联为了解非传染性疾病和心血管疾病之间的潜在共同机制提供了见解，尽管还需要进一步的研究来验证和扩展这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of the Medical Sciences 医学-医学：内科

CiteScore

4.40

自引率

0.00%

发文量

303

审稿时长

1.5 months

期刊介绍： The American Journal of The Medical Sciences (AJMS), founded in 1820, is the 2nd oldest medical journal in the United States. The AJMS is the official journal of the Southern Society for Clinical Investigation (SSCI). The SSCI is dedicated to the advancement of medical research and the exchange of knowledge, information and ideas. Its members are committed to mentoring future generations of medical investigators and promoting careers in academic medicine. The AJMS publishes, on a monthly basis, peer-reviewed articles in the field of internal medicine and its subspecialties, which include: Original clinical and basic science investigations Review articles Online Images in the Medical Sciences Special Features Include: Patient-Centered Focused Reviews History of Medicine The Science of Medical Education.