Comparisons of the oncological results of transoral laser surgery and radiotherapy for early stage laryngeal squamous cell cancer: single-center long-term results.

Annals of Saudi medicine Pub Date : 2024-07-01 Epub Date: 2024-08-01 DOI:10.5144/0256-4947.2024.213

Sumeyra Doluoglu, Omer Bayir, Bulent Ocal, Emel Cadalli Tatar, Mehmet Hakan Korkmaz, Guleser Saylam

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引用次数: 0

Abstract

Background: In the treatment of early stage laryngeal cancers, surgery (transoral laryngeal surgery (TOLS), open partial laryngeal surgery (OPLS) and radiotherapy (RT) are used.

Objectives: Compare the oncological results of patients with early stage laryngeal squamous cell carcinoma (LSCC) treated with TOLS or RT.

Design: Retrospective.

Settings: Tertiary training and research hospital.

Patients and methods: The participants were divided into patients who underwent TOLS and RT treatment. The groups were compared with each other in terms of local recurrence, regional recurrence, distant metastasis, 3 and 5-year overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS) and laryngectomy-free survival rates (LFS).

Main outcome measures: The effects of TOLS and RT treatment on local control, regional control, OS, DFS, DDS and LFS in early stage laryngeal cancers.

Sample size: 261.

Results: The mean follow-up time was 48 (26) months. There were 186 patients who underwent TOLS and 75 patients who underwent RT treatment. Gender, cigarette/alcohol consumption, tumor localization, anterior commissure involvement, tumor grades, recurrence rates and recurrence localizations of the groups were similar. The 5-year overall, disease specific, disease free and laryngectomy-free survival rates were 85.9%, 88%, 79.4%, 96.3% in the TOLS group and 74.3%, 76.7%, 72.3%, 85.2% in the RT group (P=.034, .065, .269, .060, respectively).

Conclusions: TOLS had equal and good oncological outcomes on OS and DFS compared to RT. Anterior commissure involvement was statistically significant independent prognostic risk factor for DFS in both groups. The 5-year OS rate was greater in the TOLS groups (P=.034).

Limitations: Retrospective, but to the best our knowledge, this is the first study in Turkey with a high patient volume and a long follow-up time.

查看原文本刊更多论文

经口激光手术和放疗治疗早期喉鳞状细胞癌的肿瘤效果比较：单中心长期结果。

背景：在早期喉癌的治疗中，手术（经口喉手术（TOLS）、开放部分喉手术（OPLS）和放疗（RT））是常用的方法：比较早期喉鳞状细胞癌（LSCC）患者接受TOLS或RT治疗的肿瘤效果：设计：回顾性：背景：三级培训和研究医院：参与者分为接受TOLS和RT治疗的患者。比较两组患者的局部复发率、区域复发率、远处转移率、3年和5年总生存率（OS）、无病生存率（DFS）、疾病特异性生存率（DSS）和无喉切除生存率（LFS）：主要结果指标：TOLS和RT治疗对早期喉癌的局部控制、区域控制、OS、DFS、DDS和LFS的影响：平均随访时间为 48（26）个月。结果：平均随访时间为48个月（26个月），其中186名患者接受了TOLS治疗，75名患者接受了RT治疗。两组患者的性别、吸烟/酗酒情况、肿瘤定位、前突受累情况、肿瘤分级、复发率和复发部位相似。TOLS组的5年总生存率、疾病特异性生存率、无病生存率和无喉切除生存率分别为85.9%、88%、79.4%、96.3%，RT组分别为74.3%、76.7%、72.3%、85.2%（P=.034、.065、.269、.060）：结论：TOLS与RT相比，在OS和DFS方面具有相同且良好的肿瘤治疗效果。前会阴受累是两组患者DFS具有统计学意义的独立预后风险因素。TOLS组的5年OS率更高（P=.034）：局限性：回顾性研究，但据我们所知，这是土耳其第一项病人数量多、随访时间长的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of Saudi medicine

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