Faricimab in Neovascular AMD Complicated by Pigment Epithelium Detachment: An AI-Assisted Evaluation of Early Morphological Changes.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-10-01 Epub Date: 2024-08-09 DOI:10.1007/s40123-024-01005-x

Daniele Veritti, Valentina Sarao, Marco Gonfiantini, Leopoldo Rubinato, Paolo Lanzetta

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引用次数: 0

Abstract

Introduction: This study investigates the early temporal changes in pigment epithelial detachment (PED) morphology following treatment with faricimab in patients with neovascular age-related macular degeneration (nAMD). Utilizing an artificial intelligence (AI)-assisted approach, we provide a detailed quantification and characterization of the dynamics of these morphological changes.

Methods: A prospective observational study was conducted on 22 eyes from 22 treatment-naïve patients with nAMD-associated PED (presenting either type 1 or type 3 macular neovascularization). Participants were administered intravitreal faricimab (6 mg) at baseline and at days 30, 60, and 90. Comprehensive ophthalmic evaluations and spectral-domain optical coherence tomography (SD-OCT) imaging were conducted at baseline and at seven additional follow-up visits on days 1, 7, 14, 30, 60, 90, and 120. An AI-based automated segmentation algorithm was utilized to precisely quantify changes in PED volume, alongside intraretinal (IRF) and subretinal fluid (SRF) volumes, at each time point.

Results: Treatment with faricimab resulted in a significant reduction in mean PED volume, with an average decrease of 12% at day 1, 29% at day 7, 51% at day 14, 68% at day 30, 72% at day 60, 79% at day 90, and 84% at day 120 (p < 0.0001 for all time points). Similarly rapid and marked reductions were noted in both mean IRF (23.5% at day 1, 90.7% at day 14) and SRF (14.4% at day 1, 91.2% at day 14) volumes. The study also showed a statistically significant improvement in best-corrected visual acuity (BCVA) over the follow-up period, correlating with the reduction in PED volume.

Conclusion: Faricimab demonstrates early and significant efficacy in improving PED architecture in patients with nAMD. The rapid morphological improvements observed in this study suggest faricimab may represent a valid therapeutic option for PEDs associated with nAMD.

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法尼单抗治疗并发色素上皮脱落的新生血管性老年黄斑病变：人工智能辅助评估早期形态变化。

简介本研究调查了新生血管性老年黄斑变性（nAMD）患者接受法尼单抗治疗后色素上皮脱落（PED）形态的早期时间变化。利用人工智能（AI）辅助方法，我们对这些形态变化的动态变化进行了详细的量化和表征：我们对 22 位 nAMD 相关 PED（表现为 1 型或 3 型黄斑新生血管）治疗无效患者的 22 只眼睛进行了前瞻性观察研究。参与者在基线和第 30、60 和 90 天接受了玻璃体内法尼单抗（6 毫克）治疗。在基线和第 1、7、14、30、60、90 和 120 天的七次额外随访中进行了全面的眼科评估和光谱域光学相干断层扫描（SD-OCT）成像。利用基于人工智能的自动分割算法精确量化了每个时间点PED体积的变化以及视网膜内（IRF）和视网膜下积液（SRF）的体积：结果：使用法尼单抗治疗后，平均PED体积显著减少，第1天平均减少12%，第7天减少29%，第14天减少51%，第30天减少68%，第60天减少72%，第90天减少79%，第120天减少84%（p 结论：法尼单抗在早期治疗中显示出显著的疗效：Faricimab 对改善 nAMD 患者的 PED 结构具有早期显著疗效。本研究中观察到的快速形态学改善表明，法利单抗可能是治疗与 nAMD 相关的 PED 的有效选择。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. 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