SoDCoD: a comprehensive database of Cu/Zn superoxide dismutase conformational diversity caused by ALS-linked gene mutations and other perturbations.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-08-08 DOI:10.1093/database/baae064

Riko Tabuchi, Yurika Momozawa, Yuki Hayashi, Hisashi Noma, Hidenori Ichijo, Takao Fujisawa

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Abstract

A structural alteration in copper/zinc superoxide dismutase (SOD1) is one of the common features caused by amyotrophic lateral sclerosis (ALS)-linked mutations. Although a large number of SOD1 variants have been reported in ALS patients, the detailed structural properties of each variant are not well summarized. We present SoDCoD, a database of superoxide dismutase conformational diversity, collecting our comprehensive biochemical analyses of the structural changes in SOD1 caused by ALS-linked gene mutations and other perturbations. SoDCoD version 1.0 contains information about the properties of 188 types of SOD1 mutants, including structural changes and their binding to Derlin-1, as well as a set of genes contributing to the proteostasis of mutant-like wild-type SOD1. This database provides valuable insights into the diagnosis and treatment of ALS, particularly by targeting conformational alterations in SOD1. Database URL: https://fujisawagroup.github.io/SoDCoDweb/.

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SoDCoD：由 ALS 相关基因突变和其他扰动引起的 Cu/Zn 超氧化物歧化酶构象多样性综合数据库。

铜/锌超氧化物歧化酶（SOD1）的结构改变是肌萎缩性脊髓侧索硬化症（ALS）相关突变引起的常见特征之一。虽然 ALS 患者中出现了大量 SOD1 变体，但对每种变体的详细结构特性却没有很好的总结。我们介绍了超氧化物歧化酶构象多样性数据库 SoDCoD，该数据库收集了我们对与 ALS 相关的基因突变和其他扰动引起的 SOD1 结构变化所做的全面生化分析。SoDCoD 1.0 版包含 188 种 SOD1 突变体的特性信息，包括结构变化及其与 Derlin-1 的结合，以及一组有助于突变型野生型 SOD1 蛋白稳定的基因。该数据库为 ALS 的诊断和治疗提供了有价值的见解，特别是通过靶向 SOD1 的构象改变。数据库网址：https://fujisawagroup.github.io/SoDCoDweb/。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567