Does drug-induced liver injury still occur after sevoflurane anesthesia? -A case report.

Anesthesia and pain medicine Pub Date : 2024-07-01 Epub Date: 2024-07-31 DOI:10.17085/apm.24027

Moon Ok Lee, Seonghyeon Cho, Chaeeun Kim, Hanna Koh

{"title":"Does drug-induced liver injury still occur after sevoflurane anesthesia? -A case report.","authors":"Moon Ok Lee, Seonghyeon Cho, Chaeeun Kim, Hanna Koh","doi":"10.17085/apm.24027","DOIUrl":null,"url":null,"abstract":"Background: Several factors contribute to post-anesthetic hepatic dysfunction, including a decrease in oxygen supply to the liver, direct physical compression of the liver, viral hepatitis, blood transfusions, preexisting hepatic dysfunction, and the use of hepatotoxic drugs. Diagnosing volatile anesthetic drug-induced liver injury (VA-DILI) involves excluding these causes.Case: The patient underwent total mastectomy under anesthesia using sevoflurane. He had diabetes, and no abnormal results were found on preoperative laboratory examinations, and surgery was uneventful. Abnormal laboratory findings were observed after surgery, including an aspartate aminotransferase level of 1,417 IU/L, an alanine aminotransferase level of 2,176 IU/L, and a total bilirubin level of 3.8 mg/dl. He presented with symptoms of mild icteric sclera, fatigue, and pruritus. After ruling out other causes of liver injury, we concluded that these results indicated VA-DILI.Conclusions: VA-DILI, though rare, we should be aware of the association between the disease and the use of halogenated anesthetics.","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 3","pages":"227-232"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317315/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anesthesia and pain medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17085/apm.24027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/31 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Several factors contribute to post-anesthetic hepatic dysfunction, including a decrease in oxygen supply to the liver, direct physical compression of the liver, viral hepatitis, blood transfusions, preexisting hepatic dysfunction, and the use of hepatotoxic drugs. Diagnosing volatile anesthetic drug-induced liver injury (VA-DILI) involves excluding these causes.

Case: The patient underwent total mastectomy under anesthesia using sevoflurane. He had diabetes, and no abnormal results were found on preoperative laboratory examinations, and surgery was uneventful. Abnormal laboratory findings were observed after surgery, including an aspartate aminotransferase level of 1,417 IU/L, an alanine aminotransferase level of 2,176 IU/L, and a total bilirubin level of 3.8 mg/dl. He presented with symptoms of mild icteric sclera, fatigue, and pruritus. After ruling out other causes of liver injury, we concluded that these results indicated VA-DILI.

Conclusions: VA-DILI, though rare, we should be aware of the association between the disease and the use of halogenated anesthetics.

查看原文本刊更多论文

七氟醚麻醉后是否仍会发生药物性肝损伤？-病例报告。

背景：导致麻醉后肝功能异常的因素有很多，包括肝脏供氧减少、肝脏直接受到物理压迫、病毒性肝炎、输血、原有肝功能异常以及使用肝毒性药物。诊断挥发性麻醉药物诱发的肝损伤（VA-DILI）需要排除这些原因。病例：患者在使用七氟醚的麻醉下接受了全乳房切除术。患者患有糖尿病，术前实验室检查未发现异常结果，手术顺利。术后化验结果异常，包括天冬氨酸氨基转移酶水平为1,417 IU/L，丙氨酸氨基转移酶水平为2,176 IU/L，总胆红素水平为3.8 mg/dl。他出现了轻度巩膜黄疸、乏力和瘙痒症状。在排除了其他肝损伤原因后，我们认为这些结果表明存在 VA-DILI：结论：VA-DILI 虽然罕见，但我们应该意识到这种疾病与使用卤化麻醉剂之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Anesthesia and pain medicine

CiteScore

2.30

自引率

0.00%

发文量