{"title":"Prognostic value of 18F-FDG PET/CT in postoperative recurrence of retroperitoneal liposarcoma: a single-center retrospective study.","authors":"Juntao Lang, Wenshuai Liu, Guobing Liu, Siwei Liu, Yiqiu Zhang","doi":"10.1097/MNM.0000000000001886","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Recurrence is the leading cause of tumor-related death in retroperitoneal liposarcoma (RPLPS). Variant subtypes of RPLPS determine different recurrence 18F]-fluoro-2-deoxy-D-glucose (18F-FDG) PET/computed tomography (PET/CT). This study analyzed the characteristics of different histologic subtypes of 18F-FDG PET/CT and their associations with recurrence and prognosis.</p><p><strong>Methods: </strong>Clinical-pathological information, 18F-FDG PET/CT data, recurrence, and progression-free survivals (PFS) of 83 patients with RPLPS were collected. Maximum and peak standardized uptake values (SUVmax and SUVpeak, respectively) and mean CT value (CTmean) of tumors were measured and correlated with histologic subtype. The predictability of SUVmax, SUVpeak, and CTmean for the histologic subtype was evaluated using receiver operating characteristics (ROC) max and SUVpeak for recurrence. Kaplan-Meier analysis was performed to max and SUVpeak were risk factors for recurrence.</p><p><strong>Results: </strong>Studied patients with different types of liposarcomas. Dedifferentiated liposarcomas (DDLPS) had higher SUVmax and SUVpeak than well-differentiated (WDLPS) and myxoid/round cell (MLPS) types. WDLPS had lower CTmean values compared to MLPS and DDLPS. Using ROC curves, determined cut-off values for SUVmax (5.1) to differentiate DDLPS, SUVpeak (3.0) for WDLPS, and CTmean (12.3 Hu) for WDLPS. These cut-offs were found to be best for predicting recurrence. Kaplan-Meier analysis showed that histologic subtype, SUVmax, and SUVpeak were all linked to recurrence-free survival.</p><p><strong>Conclusions: </strong>The use of SUV and CT features on 18F-FDG PET/CT imaging may increase confidence in subtype diagnosis. Patients with SUVmax > 5.1 or SUVpeak > 3.0 suggest a poor prognosis.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Medicine Communications","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MNM.0000000000001886","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Recurrence is the leading cause of tumor-related death in retroperitoneal liposarcoma (RPLPS). Variant subtypes of RPLPS determine different recurrence 18F]-fluoro-2-deoxy-D-glucose (18F-FDG) PET/computed tomography (PET/CT). This study analyzed the characteristics of different histologic subtypes of 18F-FDG PET/CT and their associations with recurrence and prognosis.
Methods: Clinical-pathological information, 18F-FDG PET/CT data, recurrence, and progression-free survivals (PFS) of 83 patients with RPLPS were collected. Maximum and peak standardized uptake values (SUVmax and SUVpeak, respectively) and mean CT value (CTmean) of tumors were measured and correlated with histologic subtype. The predictability of SUVmax, SUVpeak, and CTmean for the histologic subtype was evaluated using receiver operating characteristics (ROC) max and SUVpeak for recurrence. Kaplan-Meier analysis was performed to max and SUVpeak were risk factors for recurrence.
Results: Studied patients with different types of liposarcomas. Dedifferentiated liposarcomas (DDLPS) had higher SUVmax and SUVpeak than well-differentiated (WDLPS) and myxoid/round cell (MLPS) types. WDLPS had lower CTmean values compared to MLPS and DDLPS. Using ROC curves, determined cut-off values for SUVmax (5.1) to differentiate DDLPS, SUVpeak (3.0) for WDLPS, and CTmean (12.3 Hu) for WDLPS. These cut-offs were found to be best for predicting recurrence. Kaplan-Meier analysis showed that histologic subtype, SUVmax, and SUVpeak were all linked to recurrence-free survival.
Conclusions: The use of SUV and CT features on 18F-FDG PET/CT imaging may increase confidence in subtype diagnosis. Patients with SUVmax > 5.1 or SUVpeak > 3.0 suggest a poor prognosis.
期刊介绍：
Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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