Trabecular bone score norms in Asian-Indians and associations with serum 25(OH)D and parathyroid hormone

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Clinical Endocrinology Pub Date : 2024-08-07 DOI:10.1111/cen.15122

Velmurugan Mannar, Anand Vishal, Soma Saha, Mani Kalaivani, Devasenathipathy Kandasamy, Ravinder Goswami

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引用次数: 0

Abstract

Objective

There is limited information on population-specific norms of trabecular-bone-score (TBS) and its associated factors. Here, we provide norms of TBS in Asian-Indians and its relationship with serum 25-hydroxyvitamin D [25(OH)D] and intact-parathyroid hormone (iPTH).

Participants and Measurements

TBS, bone-mineral-density (BMD), and vertebral-fractures (VFs) were assessed using dual-energy X-ray absorptiometry in 923 healthy Asian-Indians (aged 20–60 years). Serum 25(OH)D, iPTH, T4/TSH,, glycosylated-haemoglobin (HbA1c) were measured and associations with TBS assessed using multivariable linear regression. Subjects with BMD Z-score ≤ −2.0 or ≥2.0 at any sites, VFs, TSH > 10.0 or <0.05 µIU/ml, blood-glucose >11.1 mmol/L or HbA1c > 8.0% were excluded for generating Asian-Indian norms.

Results

TBS norms were generated in 744 healthy Asian-Indians (M:F,389:385). The cut-offs generated for ‘normal’, ‘partially-degraded’, and ‘degraded’ TBS were >1.305, 1.204–1.305 and <1.204, respectively. Mean TBS was lower in females than males (p < .001). There was 75% congruency in TBS categories between Asian-Indian and existing norms. Specificity (97.8 vs. 77.9%, p < .001) and diagnostic-accuracy (97.8% vs. 78.4%, p < .001) of TBS to detect osteoporosis were higher with Asian-Indian norms. The sensitivity of ‘partially-degraded’ TBS to diagnose osteopenia was also higher with Asian-Indian norms. In multivariable regression, gender, body-mass-index (BMI), BMD-L₁-L₄, serum PTH, daily dietary-calorie intake and calcium intake were associated with TBS. Though 25(OH)D inversely correlated with PTH, 25(OH)D was not associated with TBS.

Conclusion

This study provides norms for TBS in Asian-Indians with gender-specific differences. Increasing age and higher BMI were associated with lower TBS. Associations of TBS with circulating PTH and/or 25(OH)D need confirmation in further studies.

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亚裔印度人的骨小梁评分标准以及与血清 25(OH)D 和甲状旁腺激素的关系。

目的：关于特定人群的小梁-骨分数（TBS）标准及其相关因素的信息很有限。在此，我们提供了亚裔印度人的 TBS 标准及其与血清 25- 羟维生素 D [25(OH)D] 和完整甲状旁腺激素 (iPTH) 的关系：采用双能 X 射线吸收测量法对 923 名健康的亚裔印度人（20-60 岁）的 TBS、骨矿物质密度（BMD）和脊椎骨折（VFs）进行了评估。测量了血清 25（OH）D、iPTH、T4/TSH、糖化血红蛋白（HbA1c），并使用多变量线性回归评估了与 TBS 的关系。在生成亚印标准时，排除了任何部位的 BMD Z 评分≤-2.0 或≥2.0、VFs、TSH > 10.0 或 11.1 mmol/L 或 HbA1c > 8.0% 的受试者：在 744 名健康的亚裔印度人（男：女，389：385）中生成了 TBS 标准。正常"、"部分降解 "和 "降解 "TBS 的临界值分别为 >1.305、1.204-1.305 和 1-L4，血清 PTH、每日膳食卡路里摄入量和钙摄入量与 TBS 相关。虽然 25（OH）D 与 PTH 呈反比，但 25（OH）D 与 TBS 无关：本研究提供了亚裔印度人 TBS 的标准，其中存在性别差异。年龄越大、体重指数越高，TBS 越低。TBS与循环PTH和/或25（OH）D的关系需要进一步研究证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Endocrinology 医学-内分泌学与代谢

CiteScore

6.40

自引率

3.10%

发文量

192

审稿时长

1 months

期刊介绍： Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.