Cancer-associated adipocytes in the ovarian cancer microenvironment.

IF 3.6 3区医学 Q2 ONCOLOGY

American journal of cancer research Pub Date : 2024-07-15 eCollection Date: 2024-01-01 DOI:10.62347/XZRI9189

Qiuling Cai, Jing Yang, Huiling Shen, Wenlin Xu

引用次数: 0

Abstract

The tumor microenvironment (TME) plays a critical role in high energy metabolism during tumorigenesis, progression and metastasis. Among them, adipocytes, as an important component of the TME, can transform into cancer-associated adipocytes (CAAs) through dedifferentiation via interactions with tumor cells. These CAAs provide nutrients, growth factors, cytokines and metabolites to the tumor and later transdifferentiate into other stromal cells at a later stage to alter tumor growth, metastasis and the drug response and ultimately influence the treatment and prognosis of ovarian cancer. This review outlines the physiological functions of CAAs and discusses the progress in the use of CAAs as therapeutic targets in ovarian cancer.

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卵巢癌微环境中的癌症相关脂肪细胞

肿瘤微环境（TME）在肿瘤发生、发展和转移过程中的高能量代谢中起着至关重要的作用。其中，脂肪细胞作为肿瘤微环境的重要组成部分，可通过与肿瘤细胞的相互作用，经脱分化转变为癌相关脂肪细胞（CAAs）。这些 CAA 为肿瘤提供营养、生长因子、细胞因子和代谢产物，并在后期转分化为其他基质细胞，从而改变肿瘤的生长、转移和药物反应，最终影响卵巢癌的治疗和预后。本综述概述了 CAAs 的生理功能，并讨论了利用 CAAs 作为卵巢癌治疗靶点的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of cancer research ONCOLOGY-

自引率

3.80%

发文量

263

期刊介绍： The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.