Epidemiology of ANCA vasculitis in northern Spain.

IF 4.7 2区医学 Q1 RHEUMATOLOGY

Rheumatology Pub Date : 2025-04-01 DOI:10.1093/rheumatology/keae413

Fabricio Benavides-Villanueva, Alba Herrero-Morant, Diana Prieto-Peña, Salma Al Fazazi, Vanesa Calvo-Río, Mónica Renuncio-García, Adrián Martín-Gutierrez, María Del Amparo Sánchez-Lopez, Claudia Poo-Fernandez, Clara Escagedo-Cagigas, María Rodríguez-Vidriales, Ricardo Blanco

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引用次数: 0

Abstract

Objectives: The incidence of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) shows disparate results due to variable classification criteria and heterogeneous population series. We aimed to estimate the incidence of AAV in a well-defined population with standardized classification criteria.

Methods: This was a population-based study of AAV patients diagnosed from January 2000 to December 2023 in Cantabria, northern Spain. Patients were classified according to ACR/EULAR 2022 into granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), or unclassified vasculitis if the criteria were not met. Eosinophilic granulomatosis with polyangiitis patients were not included. The annual incidence rates were estimated by cases over 1 000 000 (106) (95% CI) including overall AVV, type of AAV, sex and year of diagnosis. A literature review was also performed.

Results: We included 152 patients [80M/72F; mean age 70.6 (13.18) years]. They were classified as MPA (67; 44%), GPA (64; 42.2%), and unclassified vasculitis (21; 13.8%). Annual incidence was 13.4 (95% CI: 10, 16.8)/106 [male 14.5 (95% CI: 10.5, 18.5); female 12.1 (95% CI: 8.7, 15.6)]. The Annual incidence of MPA was 5.9 (95% CI: 4, 7.8)/106 and GPA 5.6 (95% CI: 3.9, 7.3)/106. The mean annual incidence increased from 6.1 (95% CI: 4.5, 7.7)/106 to 16.5 (595% CI: .6, 27.4)/106 in the last 3 years, particularly in GPA from 2.3 (95% CI: 0.3, 4.9)/106 to 8.2 (95% CI: 2, 14.5)/106. The prevalence of AAV was 184.7 (95% CI: 181, 188)/106.

Conclusion: During a 20-year period we found that the incidence of AAV (GPA and MPA) in northern Spain was higher than in southern Spain, but lower than northern European countries. An increase in the incidence was observed in the last years.

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西班牙北部 ANCA 血管炎的流行病学。

目的：抗中性粒细胞胞浆抗体（ANCA）相关性脉管炎（AAV）的发病率因分类标准不同和异质性人群系列而显示出不同的结果。我们的目的是根据标准化的分类标准，估算明确定义的人群中 AAV 的发病率：方法：对西班牙北部坎塔布里亚2000年1月至2023年12月期间确诊的AAV患者进行人群研究。根据 ACR/EULAR 2022 标准，患者被分为肉芽肿伴多血管炎（GPA）、显微镜下多血管炎（MPA）或未分类的血管炎（如果不符合标准）。嗜酸性粒细胞肉芽肿伴多血管炎（EGPA）患者未包括在内。年发病率按病例数超过1,000,000（106）（95% CI）估算，包括总体AVV、AAV类型、性别和诊断年份。此外还进行了文献综述：我们纳入了 152 名患者（80/72 名男性；平均年龄；70.6 ± 13.18 岁）。他们被分为 MPA（67；44%）、GPA（64；42.2%）和未分类的血管炎（21；13.8%）。年发病率为 13.4 (10-16.8)/106 [男性 14.5 (10.5-18.5)；女性 12.1 (8.7-15.6)]。MPA的年发病率为5.9 (4-7.8)/106，GPA为5.6 (3.9-7.3)/106。在过去三年中，年平均发病率从 6.1 (4.5-7.7)/106 增至 16.5 (5.6-27.4)/106，特别是 GPA 从 2.3 (0.3-4.9)/106 增至 8.2 (2-14.5)/106。AAV的发病率为184.7（181-188）/106：在 20 年的时间里，我们发现西班牙北部的 AAV（GPA 和 MPA）发病率高于西班牙南部，但低于北欧国家。最近几年，发病率有所上升。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

7.30%

发文量

1091

审稿时长

2 months

期刊介绍： Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press. Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.