Association between hydration status and the risk and all-cause mortality of diabetic kidney disease.

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-08-07 DOI:10.1080/0886022X.2024.2386154

Yayun He, Xia Wu, Yunhai Tang

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引用次数: 0

Abstract

Background: This cohort study aimed to explore the relationship between hydration status and the risk of diabetic kidney disease (DKD) as well as all-cause death in DKD patients.

Methods: Weighted univariable and multivariable logistic regression models were used to explore the association between hydration status and DKD risk in diabetic population while weighted univariable and multivariable Cox regression models were used to identify the association between hydration status and all-cause mortality in DKD patients. Kaplan-Meier curve was plotted to present the survival probability of patients with different hydration status. Estimates were presented as odds ratio (OR), and hazard ratio (HR) with 95% confidence interval (CI).

Results: The mean follow-up time was 79.74 (±1.89) months. There were 2041 participants with DKD, and 2889 participants without. At the end of the follow-up, 965 participants were alive. The risk of DKD was increased as the increase of osmolarity level (OR = 1.07, 95%CI: 1.05-1.08). The elevated risk of DKD was observed in patients with impending dehydration (OR = 1.49, 95%CI: 1.19-1.85) or current dehydration (OR = 2.69, 95%CI: 2.09-3.46). The association between increased osmolarty level and elevated risk of all-cause mortality in DKD patients was statistically different (HR = 1.02, 95%CI: 1.01-1.03). Current dehydration was correlated with increased all-cause mortality risk in DKD patients (HR = 1.27, 95%CI: 1.01-1.61). Compared to DKD patients with normal hydration, the survival probability of DKD patients with current dehydration was significant lower (p < 0.001).

Conclusion: Increased osmolarity level was associated with increased risk of DKD and elevated risk of all-cause mortality in DKD patients.

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水合状态与糖尿病肾病的风险和全因死亡率之间的关系。

背景：这项队列研究旨在探讨水合状态与糖尿病肾病（DKD）患者的风险以及全因死亡之间的关系：这项队列研究旨在探讨水合状态与糖尿病肾病（DKD）风险以及 DKD 患者全因死亡之间的关系：方法：采用加权单变量和多变量逻辑回归模型探讨糖尿病人群的水合状态与 DKD 风险之间的关系，同时采用加权单变量和多变量 Cox 回归模型确定 DKD 患者的水合状态与全因死亡率之间的关系。绘制 Kaplan-Meier 曲线以显示不同水合状态患者的生存概率。结果显示：平均随访时间为 79.74 小时，平均死亡率为 0.5%：平均随访时间为 79.74 (±1.89) 个月。其中 2041 人患有 DKD，2889 人未患有 DKD。在随访结束时，965 名参与者存活。DKD的风险随着渗透压水平的升高而增加（OR = 1.07，95%CI：1.05-1.08）。在即将脱水（OR = 1.49，95%CI：1.19-1.85）或正在脱水（OR = 2.69，95%CI：2.09-3.46）的患者中观察到 DKD 风险升高。在 DKD 患者中，渗透压水平升高与全因死亡风险升高之间存在统计学差异（HR = 1.02，95%CI：1.01-1.03）。当前脱水与 DKD 患者全因死亡风险增加相关（HR = 1.27，95%CI：1.01-1.61）。与水合正常的 DKD 患者相比，当前脱水的 DKD 患者的生存概率明显降低（p 结论：与水合正常的 DKD 患者相比，当前脱水的 DKD 患者的生存概率明显降低：渗透压水平升高与 DKD 患者的 DKD 风险增加和全因死亡风险升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.