Retinal Vessel Functional Responses in South Africans Living With and Without HIV: The EndoAfrica-NWU Study

IF 1.9 4区 医学 Q3 HEMATOLOGY
Catharina Elizabeth Myburgh-Jacobsz, Shani Botha-Le Roux, Konstantin Kotliar, Annemarie Wentzel, Adriaan Jacobs, Patrick De Boever, Nandu Goswami, Hans Strijdom, Wayne Smith
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Abstract

Objectives

The effects of HIV and antiretroviral therapy (ART) on microvascular function are poorly explored. We compared retinal vessel functional responses to flicker light-induced provocation (FLIP) in people living with HIV (PLWH) and people living without HIV (PLWoutH).

Methods

We included 115 PLWH and 51 PLWoutH with a median age of 41 years. Treated PLWH received similar first-line fixed-dose combination ART. Clinical characteristics and retinal vessels functional responses to FLIP were compared in (a) PLWH and PLWoutH; and (b) PLWH groups stratified by the median of (i) CD4-count (511 cells/mm3), (ii) viral load (50 copies/mL), and (iii) ART duration (57.6 months).

Results

PLWH were older, smoked more, and had a lower prevalence of hypertension than PLWoutH (p < 0.05). Almost 64% of PLWH were infected for more than 5 years. Retinal vessel responses to FLIP were similar between PLWH and PLWoutH after taking confounders into account. In addition, PLWH subgroups stratified according to immuno-virological status by CD4-count, viral load, and ART duration showed no differences in retinal vessel responses to FLIP.

Conclusion

Living with HIV and receiving ART were not associated with altered microvascular function as assessed with dynamic retinal vessel analysis in a South African case–control study.

Abstract Image

南非艾滋病病毒感染者和非艾滋病病毒感染者的视网膜血管功能反应:EndoAfrica-NWU 研究。
目的:艾滋病病毒和抗逆转录病毒疗法(ART)对微血管功能的影响尚未得到充分研究。我们比较了 HIV 感染者(PLWH)和非 HIV 感染者(PLWoutH)的视网膜血管对闪烁光诱导(FLIP)的功能反应:研究对象包括 115 名艾滋病病毒感染者和 51 名非艾滋病病毒感染者,中位年龄为 41 岁。接受治疗的 PLWH 接受类似的一线固定剂量联合抗逆转录病毒疗法。比较了(a) PLWH 和 PLWoutH;(b) 按(i) CD4 细胞数(511 cells/mm3)、(ii) 病毒载量(50 copies/mL)和(iii) ART 持续时间(57.6 个月)中位数分层的 PLWH 组的临床特征和对 FLIP 的视网膜血管功能反应:结果:与未感染艾滋病毒的 PLWH 相比,感染艾滋病毒的 PLWH 年龄更大、吸烟更多,高血压患病率更低(P在南非的一项病例对照研究中,通过动态视网膜血管分析评估发现,感染艾滋病毒和接受抗逆转录病毒疗法与微血管功能的改变无关。
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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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